Detailed information of TA system TA114222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1627061..1627595
• Replicon: chromosome
• Accession: NZ_CP033747
• Organism: Burkholderia multivorans strain FDAARGOS_548

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EGY19_RS28280
• Protein ID: WP_105769202.1
• Coordinates: 1627296..1627595 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: EGY19_RS28275
• Protein ID: WP_105773713.1
• Coordinates: 1627061..1627306 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY19_RS28260	1622108..1623811	+	1704	WP_105773712.1	VRR-NUC domain-containing protein	-
EGY19_RS28265	1623808..1626108	+	2301	WP_105773728.1	ATP-dependent DNA helicase	-
EGY19_RS28270	1626152..1626922	-	771	WP_006403543.1	helix-turn-helix domain-containing protein	-
EGY19_RS28275	1627061..1627306	+	246	WP_105773713.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EGY19_RS28280	1627296..1627595	+	300	WP_105769202.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGY19_RS28285	1627704..1629005	-	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EGY19_RS28290	1629228..1630535	-	1308	WP_060041937.1	shikimate transporter	-
EGY19_RS28300	1630889..1632016	+	1128	WP_006397054.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11596.13 Da
• Isoelectric Point: 7.3154

>T114222 WP_105769202.1 NZ_CP033747:1627296-1627595 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSTAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETP
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T114222 NZ_CP033747:1627296-1627595 [Burkholderia multivorans]
ATGCCGGTTAAGGCGCGCACGGTACGTCTGACGCCACTGGCGGAGGCCGACCTCGAGGCCATCTGGGCTTACACGTACGA
GCGCTGGTCGCTCGACCAGGCTGAGCGCTATATCGGCGAGCTGAGCACGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGTCGCGCGGGCGGCAACTATTCGCGCTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGCCC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8574.67 Da
• Isoelectric Point: 7.2028

>AT114222 WP_105773713.1 NZ_CP033747:1627061-1627306 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETALRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT114222 NZ_CP033747:1627061-1627306 [Burkholderia multivorans]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGGCCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGCGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCTCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA