Detailed information of TA system TA114219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2272673..2273373
• Replicon: chromosome
• Accession: NZ_CP033745
• Organism: Burkholderia multivorans strain FDAARGOS_548

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A2S9M997
• Locus tag: EGY19_RS11145
• Protein ID: WP_035951940.1
• Coordinates: 2272673..2273050 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: EGY19_RS11150
• Protein ID: WP_054317404.1
• Coordinates: 2273050..2273373 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY19_RS11120	2268253..2268702	+	450	WP_006413500.1	VOC family protein	-
EGY19_RS11125	2268806..2270356	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
EGY19_RS11130	2270353..2270586	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
EGY19_RS11135	2270783..2271700	-	918	WP_006413492.1	spermidine synthase	-
EGY19_RS11140	2271928..2272182	+	255	WP_105771787.1	hypothetical protein	-
EGY19_RS11145	2272673..2273050	+	378	WP_035951940.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGY19_RS11150	2273050..2273373	+	324	WP_054317404.1	helix-turn-helix domain-containing protein	Antitoxin
EGY19_RS11155	2273396..2273887	-	492	WP_006413503.1	DNA-deoxyinosine glycosylase	-
EGY19_RS11160	2273884..2274498	-	615	WP_105771786.1	chorismate lyase	-
EGY19_RS11165	2274507..2276405	-	1899	WP_105771785.1	molecular chaperone HtpG	-
EGY19_RS11170	2276565..2278025	-	1461	WP_060115217.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13604.61 Da
• Isoelectric Point: 9.5844

>T114219 WP_035951940.1 NZ_CP033745:2272673-2273050 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARRDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T114219 NZ_CP033745:2272673-2273050 [Burkholderia multivorans]
ATGGGTATAAATTCGTCGATGGTTCCATACACTAAACCGCTTTACTGGCTCGGCTCGGCACGCAGGGACTTGAAAGCGAT
GCCCGAAGCGGTACAGGACACGTTCGGCTATGCGCTGTATCTGGCCCAGACGGGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGCTTCGGATCGGCCGGCGTGCTCGAGGTCGTGGAGTCGGAGGACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACACCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGGGCCGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11858.78 Da
• Isoelectric Point: 8.0686

>AT114219 WP_054317404.1 NZ_CP033745:2273050-2273373 [Burkholderia multivorans]
MIEIERGSGNVYADLGMPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT114219 NZ_CP033745:2273050-2273373 [Burkholderia multivorans]
ATGATCGAAATCGAACGGGGCAGCGGCAACGTCTACGCGGATCTGGGCATGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCGGCCAAGATCGCGGAGATCATCAAGACCCGCAAATGGACGCAGCAGCACGCGGCGCGGTTGCTCGGCATGA
CGCAACCGAAGCTATCGAACATGCTGCGCGGGCAGTTTCGCGGCGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGACGCGATGTCCAGATCGTCGTAGGACCGGACCGTCATTCGGAAACCGAAGGACACATCGAAGTCGTATTCGCTGC
CTGA

Structures

Toxin

• AlphaFold DB: A0A2S9M997