Detailed information of TA system TA114217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 99083..99720
• Replicon: chromosome
• Accession: NZ_CP033745
• Organism: Burkholderia multivorans strain FDAARGOS_548

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EGY19_RS00475
• Protein ID: WP_105772017.1
• Coordinates: 99319..99720 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: EGY19_RS00470
• Protein ID: WP_105772018.1
• Coordinates: 99083..99319 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY19_RS00440	94347..94889	+	543	WP_006401432.1	hypothetical protein	-
EGY19_RS00450	95052..95978	+	927	WP_123876276.1	helix-turn-helix domain-containing protein	-
EGY19_RS00455	96106..97194	-	1089	WP_105772020.1	ADP-heptose--LPS heptosyltransferase	-
EGY19_RS00460	97191..98894	-	1704	WP_105772019.1	thiamine pyrophosphate-binding protein	-
EGY19_RS00470	99083..99319	+	237	WP_105772018.1	AbrB family transcriptional regulator	Antitoxin
EGY19_RS00475	99319..99720	+	402	WP_105772017.1	type II toxin-antitoxin system VapC family toxin	Toxin
EGY19_RS00480	99842..101230	-	1389	WP_006401425.1	L-serine ammonia-lyase	-
EGY19_RS00485	101257..102399	-	1143	WP_006401424.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14958.16 Da
• Isoelectric Point: 6.2246

>T114217 WP_105772017.1 NZ_CP033745:99319-99720 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNHERDFASYPGLRLENWLVG

Nucleotide

• Length: 402 bp

>T114217 NZ_CP033745:99319-99720 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGGTATGTGCCAATC
CGGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTTGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TACGGCCCCATTCGCGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCATGCCGTATCGCT
CGACGTCGTGCTGGTGACCAACCACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTCGAGAACTGGCTGGTCGGCT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8972.05 Da
• Isoelectric Point: 5.8651

>AT114217 WP_105772018.1 NZ_CP033745:99083-99319 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPANLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREDW

Nucleotide

• Length: 237 bp

>AT114217 NZ_CP033745:99083-99319 [Burkholderia multivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGAATCTGGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGATGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGATTGGTGA