Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1806282..1806936 Replicon chromosome
Accession NZ_CP033744
Organism Citrobacter freundii strain FDAARGOS_549

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag EGX89_RS09565 Protein ID WP_003026936.1
Coordinates 1806282..1806689 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag EGX89_RS09570 Protein ID WP_003026938.1
Coordinates 1806670..1806936 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX89_RS09545 1802230..1803963 - 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -
EGX89_RS09550 1803969..1804682 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EGX89_RS09555 1804706..1805602 - 897 WP_061549190.1 site-specific tyrosine recombinase XerD -
EGX89_RS09560 1805716..1806237 + 522 WP_003026933.1 flavodoxin FldB -
EGX89_RS09565 1806282..1806689 - 408 WP_003026936.1 protein YgfX Toxin
EGX89_RS09570 1806670..1806936 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
EGX89_RS09575 1807193..1808173 + 981 WP_121572017.1 tRNA-modifying protein YgfZ -
EGX89_RS09580 1808267..1808926 - 660 WP_003838267.1 hemolysin III family protein -
EGX89_RS09585 1809089..1809400 - 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
EGX89_RS09590 1809453..1810181 + 729 WP_060855085.1 MurR/RpiR family transcriptional regulator -
EGX89_RS09595 1810302..1811735 + 1434 WP_049000999.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T114212 WP_003026936.1 NZ_CP033744:c1806689-1806282 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T114212 NZ_CP033744:c1806689-1806282 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATAGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT114212 WP_003026938.1 NZ_CP033744:c1806936-1806670 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT114212 NZ_CP033744:c1806936-1806670 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References