Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3202164..3202867 Replicon chromosome
Accession NZ_CP033742
Organism Citrobacter freundii strain FDAARGOS_550

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag EGY10_RS15700 Protein ID WP_089586935.1
Coordinates 3202526..3202867 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag EGY10_RS15695 Protein ID WP_058647031.1
Coordinates 3202164..3202505 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY10_RS15660 3197315..3198190 + 876 WP_058647036.1 GTPase family protein -
EGY10_RS15665 3198434..3199150 + 717 WP_058647035.1 WYL domain-containing protein -
EGY10_RS15670 3199186..3199638 + 453 WP_089586936.1 hypothetical protein -
EGY10_RS15675 3199710..3200183 + 474 WP_058647034.1 hypothetical protein -
EGY10_RS15680 3200303..3201124 + 822 WP_058647033.1 DUF945 domain-containing protein -
EGY10_RS15685 3201155..3201598 + 444 WP_058647032.1 antirestriction protein -
EGY10_RS15690 3201611..3202153 + 543 WP_080395938.1 DNA repair protein RadC -
EGY10_RS15695 3202164..3202505 + 342 WP_058647031.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EGY10_RS15700 3202526..3202867 + 342 WP_089586935.1 TA system toxin CbtA family protein Toxin
EGY10_RS15705 3203233..3204105 - 873 WP_121540721.1 HNH endonuclease -
EGY10_RS15710 3204246..3204881 + 636 WP_121540722.1 HNH endonuclease -
EGY10_RS15715 3204928..3205290 - 363 WP_048219798.1 endoribonuclease SymE -
EGY10_RS15720 3206069..3207439 + 1371 WP_003837154.1 tyrosine phenol-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12677.63 Da        Isoelectric Point: 8.0323

>T114199 WP_089586935.1 NZ_CP033742:3202526-3202867 [Citrobacter freundii]
MKTLPAITPQAATLCLSPVAVWQMLLTRLLEQHYGLTLNDTQFSDETVIQEHIDAGITLANAVNFLVVKYELVRIDRKGL
SWQEQSPYLRAVDILRARQATGLLRRNSSNSGL

Download         Length: 342 bp

>T114199 NZ_CP033742:3202526-3202867 [Citrobacter freundii]
ATGAAAACTCTACCTGCAATAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCTGTGGCAGTCTGGCAAATGTTACTGAC
ACGCCTGTTGGAACAGCACTATGGTCTTACACTAAACGATACGCAGTTCAGTGATGAAACGGTTATACAGGAACATATCG
ATGCCGGTATTACTCTGGCTAATGCCGTTAACTTTTTGGTGGTGAAATATGAATTGGTTCGTATCGATCGCAAAGGACTT
AGCTGGCAAGAGCAGTCCCCATATCTTCGGGCTGTAGATATTCTCCGGGCACGACAGGCAACTGGCTTGTTGCGACGAAA
CAGTAGTAACTCCGGATTGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12820.44 Da        Isoelectric Point: 5.5353

>AT114199 WP_058647031.1 NZ_CP033742:3202164-3202505 [Citrobacter freundii]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLYYLADRASITGEFNNAESLKLDEVLPHFISQMESMLTTGEMNPRH
AHCVTLYHNCFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 342 bp

>AT114199 NZ_CP033742:3202164-3202505 [Citrobacter freundii]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTAAAATGGGGACTGAATCGTAATGTGACACCTTGCTTTGGTGCTCG
TCTAGTACAGGAGGGAAACCGGTTGTACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAATAATGCAGAATCTT
TGAAGTTGGATGAAGTACTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAACCCTCGCCAT
GCCCACTGTGTCACTCTGTACCACAATTGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGC
CATTTATCCCACACAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References