Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 56707..57844 Replicon plasmid unnamed2
Accession NZ_CP033741
Organism Enterococcus sp. FDAARGOS_553

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag EGX73_RS15820 Protein ID WP_123867122.1
Coordinates 56707..57570 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag EGX73_RS15825 Protein ID WP_000301765.1
Coordinates 57572..57844 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX73_RS15800 52757..53233 - 477 Protein_53 hypothetical protein -
EGX73_RS15805 53568..53936 + 369 WP_123867120.1 metalloregulator ArsR/SmtB family transcription factor -
EGX73_RS15810 53929..56058 + 2130 WP_115234514.1 cadmium-translocating P-type ATPase -
EGX73_RS15815 56094..56555 + 462 WP_123867121.1 copper chaperone Copz family protein -
EGX73_RS15820 56707..57570 - 864 WP_123867122.1 zeta toxin family protein Toxin
EGX73_RS15825 57572..57844 - 273 WP_000301765.1 antitoxin Antitoxin
EGX73_RS15830 57861..58070 - 210 WP_000527318.1 peptide-binding protein -
EGX73_RS15835 58217..60361 - 2145 WP_123867123.1 type IA DNA topoisomerase -
EGX73_RS15840 60400..60648 - 249 WP_070629349.1 hypothetical protein -
EGX73_RS15845 60665..60877 - 213 WP_031644655.1 hypothetical protein -
EGX73_RS15850 60899..61288 - 390 WP_056948698.1 hypothetical protein -
EGX73_RS15855 61361..61963 - 603 WP_031644647.1 recombinase family protein -
EGX73_RS16025 61977..62147 - 171 WP_164742224.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..64163 64163


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32497.13 Da        Isoelectric Point: 7.3945

>T114186 WP_123867122.1 NZ_CP033741:c57570-56707 [Enterococcus sp. FDAARGOS_553]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTEVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPNNLETLKKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVASKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLRPPTPPIPKTPKLPGI

Download         Length: 864 bp

>T114186 NZ_CP033741:c57570-56707 [Enterococcus sp. FDAARGOS_553]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGAAGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAGCAAGCACATGATATTGTTGTTAAAAATTTACCTAA
CAATTTAGAAACACTTAAAAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTAGCAAGTAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCGGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT114186 WP_000301765.1 NZ_CP033741:c57844-57572 [Enterococcus sp. FDAARGOS_553]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT114186 NZ_CP033741:c57844-57572 [Enterococcus sp. FDAARGOS_553]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References