Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 3192129..3193099 Replicon chromosome
Accession NZ_CP033736
Organism Proteus vulgaris strain FDAARGOS_556

Toxin (Protein)


Gene name panT Uniprot ID A0A0G4QEB6
Locus tag EGX81_RS14985 Protein ID WP_072063026.1
Coordinates 3192692..3193099 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0G4Q2R5
Locus tag EGX81_RS14980 Protein ID WP_072063025.1
Coordinates 3192129..3192695 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX81_RS14960 3187970..3189085 - 1116 WP_123822411.1 spermidine/putrescine ABC transporter ATP-binding protein PotA -
EGX81_RS14965 3189631..3190926 - 1296 WP_082239440.1 S8 family serine peptidase -
EGX81_RS14970 3191087..3191677 - 591 WP_036934555.1 CbrC family protein -
EGX81_RS14980 3192129..3192695 + 567 WP_072063025.1 SocA family protein Antitoxin
EGX81_RS14985 3192692..3193099 + 408 WP_072063026.1 hypothetical protein Toxin
EGX81_RS14990 3193231..3194691 - 1461 WP_123822412.1 hypothetical protein -
EGX81_RS14995 3194709..3198047 - 3339 WP_123822413.1 DUF1983 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3187970..3234683 46713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-141)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15418.73 Da        Isoelectric Point: 7.1983

>T114185 WP_072063026.1 NZ_CP033736:3192692-3193099 [Proteus vulgaris]
MIDYQPYKRGTVLAPTGPCEHLHVVCNDPVYYPINGCDCVLVVNISSCKEGVPFDATCLLKPGDHDFIRHDSYVVYREAI
IWRVPNVISRVQTGEIIPRSDVSFDVFKRINAGFGISEQVIPKNFKFWRTFCSNY

Download         Length: 408 bp

>T114185 NZ_CP033736:3192692-3193099 [Proteus vulgaris]
ATGATTGATTATCAACCATATAAAAGAGGTACGGTGTTAGCACCAACAGGCCCATGTGAGCATTTACACGTTGTTTGCAA
TGATCCTGTTTATTACCCCATTAATGGTTGTGATTGTGTTTTGGTTGTAAATATATCAAGTTGTAAAGAGGGTGTCCCAT
TCGATGCAACCTGCTTATTAAAACCAGGAGATCATGATTTTATTCGACATGATAGTTACGTGGTTTATAGAGAAGCTATC
ATTTGGCGAGTTCCAAATGTTATTTCAAGAGTTCAGACAGGCGAAATTATTCCGAGAAGCGATGTTAGCTTTGATGTATT
TAAAAGGATAAACGCAGGTTTTGGTATTTCAGAACAAGTAATCCCAAAAAACTTTAAATTTTGGCGTACTTTTTGTTCTA
ATTATTAG

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21350.27 Da        Isoelectric Point: 4.9537

>AT114185 WP_072063025.1 NZ_CP033736:3192129-3192695 [Proteus vulgaris]
MFCEEKVAQMAAYLLHKRGGRMAYIKLMKLLYLADRECLIRFGDSMSGDSYVSMNHGPVLSRTYDLVKSGGDYDDSPWEL
WISGEANYEVSIKKVLSGVMDDDFDELSKADIKILDETFSKYGHLKRFRICDLTHEICPEWNDPHGSSIPINPRDIFLAG
GKTEQEADACLRSFNETKQLKAFSSELA

Download         Length: 567 bp

>AT114185 NZ_CP033736:3192129-3192695 [Proteus vulgaris]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTGCATAAACGCGGTGGGCGCATGGCATACATAAAATT
AATGAAACTTCTTTACCTTGCTGATAGAGAGTGCTTAATTAGATTTGGTGACTCTATGTCAGGAGACAGCTACGTTTCTA
TGAATCATGGACCTGTTTTATCCAGAACTTATGATTTAGTTAAATCTGGTGGAGATTATGATGATTCTCCATGGGAATTA
TGGATCTCTGGTGAGGCTAACTATGAAGTTAGCATAAAAAAAGTATTGTCAGGTGTTATGGACGATGATTTTGATGAGCT
AAGTAAAGCGGATATAAAAATACTTGATGAGACTTTTTCCAAGTATGGACACCTGAAAAGGTTTCGAATTTGCGATTTAA
CTCATGAAATATGTCCAGAGTGGAATGATCCTCATGGTTCATCTATCCCCATTAACCCAAGAGACATATTTCTAGCTGGC
GGTAAGACTGAACAAGAAGCGGATGCGTGCTTGCGAAGTTTTAATGAAACTAAACAGCTCAAGGCATTTAGTTCTGAATT
AGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G4QEB6

Antitoxin

Source ID Structure
AlphaFold DB A0A0G4Q2R5

References