Detailed information of TA system TA114184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 2049134..2050104
• Replicon: chromosome
• Accession: NZ_CP033736
• Organism: Proteus vulgaris strain FDAARGOS_556

Toxin (Protein)

• Gene name: panT
• Uniprot ID: A0A0G4QEB6
• Locus tag: EGX81_RS09735
• Protein ID: WP_072063026.1
• Coordinates: 2049697..2050104 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0G4Q2R5
• Locus tag: EGX81_RS09730
• Protein ID: WP_072063025.1
• Coordinates: 2049134..2049700 (+)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX81_RS09690	2044290..2044643	+	354	WP_036935781.1	flagella biosynthesis regulatory protein FliT	-
EGX81_RS09695	2044777..2045232	-	456	WP_036935779.1	GNAT family N-acetyltransferase	-
EGX81_RS09700	2045382..2046515	-	1134	WP_036935777.1	hypothetical protein	-
EGX81_RS09705	2046873..2047088	-	216	WP_006533140.1	hypothetical protein	-
EGX81_RS09710	2047193..2047423	-	231	WP_036938942.1	hypothetical protein	-
EGX81_RS09715	2047478..2047816	-	339	WP_179951916.1	GlpM family protein	-
EGX81_RS09720	2047892..2048143	-	252	WP_036935774.1	hypothetical protein	-
EGX81_RS09725	2048710..2048940	+	231	WP_123822210.1	DNA polymerase III subunit theta	-
EGX81_RS09730	2049134..2049700	+	567	WP_072063025.1	SocA family protein	Antitoxin
EGX81_RS09735	2049697..2050104	+	408	WP_072063026.1	hypothetical protein	Toxin
EGX81_RS09740	2050236..2051696	-	1461	WP_123822260.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliC	1980952..2100613	119661

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-141)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15418.73 Da
• Isoelectric Point: 7.1983

>T114184 WP_072063026.1 NZ_CP033736:2049697-2050104 [Proteus vulgaris]
MIDYQPYKRGTVLAPTGPCEHLHVVCNDPVYYPINGCDCVLVVNISSCKEGVPFDATCLLKPGDHDFIRHDSYVVYREAI
IWRVPNVISRVQTGEIIPRSDVSFDVFKRINAGFGISEQVIPKNFKFWRTFCSNY

Nucleotide

• Length: 408 bp

>T114184 NZ_CP033736:2049697-2050104 [Proteus vulgaris]
ATGATTGATTATCAACCATATAAAAGAGGTACGGTGTTAGCACCAACAGGCCCATGTGAGCATTTACACGTTGTTTGCAA
TGATCCTGTTTATTACCCCATTAATGGTTGTGATTGTGTTTTGGTTGTAAATATATCAAGTTGTAAAGAGGGTGTCCCAT
TCGATGCAACCTGCTTATTAAAACCAGGAGATCATGATTTTATTCGACATGATAGTTACGTGGTTTATAGAGAAGCTATC
ATTTGGCGAGTTCCAAATGTTATTTCAAGAGTTCAGACAGGCGAAATTATTCCGAGAAGCGATGTTAGCTTTGATGTATT
TAAAAGGATAAACGCAGGTTTTGGTATTTCAGAACAAGTAATCCCAAAAAACTTTAAATTTTGGCGTACTTTTTGTTCTA
ATTATTAG

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 21350.27 Da
• Isoelectric Point: 4.9537

>AT114184 WP_072063025.1 NZ_CP033736:2049134-2049700 [Proteus vulgaris]
MFCEEKVAQMAAYLLHKRGGRMAYIKLMKLLYLADRECLIRFGDSMSGDSYVSMNHGPVLSRTYDLVKSGGDYDDSPWEL
WISGEANYEVSIKKVLSGVMDDDFDELSKADIKILDETFSKYGHLKRFRICDLTHEICPEWNDPHGSSIPINPRDIFLAG
GKTEQEADACLRSFNETKQLKAFSSELA

Nucleotide

• Length: 567 bp

>AT114184 NZ_CP033736:2049134-2049700 [Proteus vulgaris]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTGCATAAACGCGGTGGGCGCATGGCATACATAAAATT
AATGAAACTTCTTTACCTTGCTGATAGAGAGTGCTTAATTAGATTTGGTGACTCTATGTCAGGAGACAGCTACGTTTCTA
TGAATCATGGACCTGTTTTATCCAGAACTTATGATTTAGTTAAATCTGGTGGAGATTATGATGATTCTCCATGGGAATTA
TGGATCTCTGGTGAGGCTAACTATGAAGTTAGCATAAAAAAAGTATTGTCAGGTGTTATGGACGATGATTTTGATGAGCT
AAGTAAAGCGGATATAAAAATACTTGATGAGACTTTTTCCAAGTATGGACACCTGAAAAGGTTTCGAATTTGCGATTTAA
CTCATGAAATATGTCCAGAGTGGAATGATCCTCATGGTTCATCTATCCCCATTAACCCAAGAGACATATTTCTAGCTGGC
GGTAAGACTGAACAAGAAGCGGATGCGTGCTTGCGAAGTTTTAATGAAACTAAACAGCTCAAGGCATTTAGTTCTGAATT
AGCATGA

Structures

Toxin

• AlphaFold DB: A0A0G4QEB6

Antitoxin

• AlphaFold DB: A0A0G4Q2R5