Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 1985308..1986278 Replicon chromosome
Accession NZ_CP033736
Organism Proteus vulgaris strain FDAARGOS_556

Toxin (Protein)


Gene name panT Uniprot ID A0A0G4QEB6
Locus tag EGX81_RS09245 Protein ID WP_072063026.1
Coordinates 1985871..1986278 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0G4Q2R5
Locus tag EGX81_RS09240 Protein ID WP_072063025.1
Coordinates 1985308..1985874 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX81_RS09200 1980465..1980818 + 354 WP_036935781.1 flagella biosynthesis regulatory protein FliT -
EGX81_RS09205 1980952..1981407 - 456 WP_036935779.1 GNAT family N-acetyltransferase -
EGX81_RS09210 1981557..1982690 - 1134 WP_036935777.1 hypothetical protein -
EGX81_RS09215 1983047..1983262 - 216 WP_006533140.1 hypothetical protein -
EGX81_RS09220 1983367..1983597 - 231 WP_036938942.1 hypothetical protein -
EGX81_RS09225 1983652..1983990 - 339 WP_179951916.1 GlpM family protein -
EGX81_RS09230 1984066..1984317 - 252 WP_036935774.1 hypothetical protein -
EGX81_RS09235 1984884..1985114 + 231 WP_123822210.1 DNA polymerase III subunit theta -
EGX81_RS09240 1985308..1985874 + 567 WP_072063025.1 SocA family protein Antitoxin
EGX81_RS09245 1985871..1986278 + 408 WP_072063026.1 hypothetical protein Toxin
EGX81_RS09250 1987030..1987236 - 207 WP_123822211.1 hypothetical protein -
EGX81_RS09255 1987573..1987832 - 260 Protein_1812 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliC 1980952..2100613 119661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-141)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15418.73 Da        Isoelectric Point: 7.1983

>T114183 WP_072063026.1 NZ_CP033736:1985871-1986278 [Proteus vulgaris]
MIDYQPYKRGTVLAPTGPCEHLHVVCNDPVYYPINGCDCVLVVNISSCKEGVPFDATCLLKPGDHDFIRHDSYVVYREAI
IWRVPNVISRVQTGEIIPRSDVSFDVFKRINAGFGISEQVIPKNFKFWRTFCSNY

Download         Length: 408 bp

>T114183 NZ_CP033736:1985871-1986278 [Proteus vulgaris]
ATGATTGATTATCAACCATATAAAAGAGGTACGGTGTTAGCACCAACAGGCCCATGTGAGCATTTACACGTTGTTTGCAA
TGATCCTGTTTATTACCCCATTAATGGTTGTGATTGTGTTTTGGTTGTAAATATATCAAGTTGTAAAGAGGGTGTCCCAT
TCGATGCAACCTGCTTATTAAAACCAGGAGATCATGATTTTATTCGACATGATAGTTACGTGGTTTATAGAGAAGCTATC
ATTTGGCGAGTTCCAAATGTTATTTCAAGAGTTCAGACAGGCGAAATTATTCCGAGAAGCGATGTTAGCTTTGATGTATT
TAAAAGGATAAACGCAGGTTTTGGTATTTCAGAACAAGTAATCCCAAAAAACTTTAAATTTTGGCGTACTTTTTGTTCTA
ATTATTAG

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21350.27 Da        Isoelectric Point: 4.9537

>AT114183 WP_072063025.1 NZ_CP033736:1985308-1985874 [Proteus vulgaris]
MFCEEKVAQMAAYLLHKRGGRMAYIKLMKLLYLADRECLIRFGDSMSGDSYVSMNHGPVLSRTYDLVKSGGDYDDSPWEL
WISGEANYEVSIKKVLSGVMDDDFDELSKADIKILDETFSKYGHLKRFRICDLTHEICPEWNDPHGSSIPINPRDIFLAG
GKTEQEADACLRSFNETKQLKAFSSELA

Download         Length: 567 bp

>AT114183 NZ_CP033736:1985308-1985874 [Proteus vulgaris]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTGCATAAACGCGGTGGGCGCATGGCATACATAAAATT
AATGAAACTTCTTTACCTTGCTGATAGAGAGTGCTTAATTAGATTTGGTGACTCTATGTCAGGAGACAGCTACGTTTCTA
TGAATCATGGACCTGTTTTATCCAGAACTTATGATTTAGTTAAATCTGGTGGAGATTATGATGATTCTCCATGGGAATTA
TGGATCTCTGGTGAGGCTAACTATGAAGTTAGCATAAAAAAAGTATTGTCAGGTGTTATGGACGATGATTTTGATGAGCT
AAGTAAAGCGGATATAAAAATACTTGATGAGACTTTTTCCAAGTATGGACACCTGAAAAGGTTTCGAATTTGCGATTTAA
CTCATGAAATATGTCCAGAGTGGAATGATCCTCATGGTTCATCTATCCCCATTAACCCAAGAGACATATTTCTAGCTGGC
GGTAAGACTGAACAAGAAGCGGATGCGTGCTTGCGAAGTTTTAATGAAACTAAACAGCTCAAGGCATTTAGTTCTGAATT
AGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G4QEB6

Antitoxin

Source ID Structure
AlphaFold DB A0A0G4Q2R5

References