Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1581846..1582655 Replicon chromosome
Accession NZ_CP033735
Organism Staphylococcus cohnii strain FDAARGOS_538

Toxin (Protein)


Gene name tsbT Uniprot ID A0A0M2NVX1
Locus tag EGX68_RS08055 Protein ID WP_019468112.1
Coordinates 1581846..1582031 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0M2NXJ1
Locus tag EGX68_RS08060 Protein ID WP_019468111.1
Coordinates 1582056..1582655 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX68_RS08035 1577260..1578369 - 1110 WP_019468116.1 GAF domain-containing sensor histidine kinase -
EGX68_RS08040 1578561..1579388 + 828 WP_019468115.1 RluA family pseudouridine synthase -
EGX68_RS08045 1579557..1580942 - 1386 WP_019468114.1 class II fumarate hydratase -
EGX68_RS08050 1581140..1581553 - 414 WP_019468113.1 hypothetical protein -
EGX68_RS08055 1581846..1582031 - 186 WP_019468112.1 hypothetical protein Toxin
EGX68_RS08060 1582056..1582655 - 600 WP_019468111.1 glucosamine-6-phosphate isomerase Antitoxin
EGX68_RS08065 1582835..1583305 - 471 WP_019468110.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EGX68_RS08070 1583311..1584438 - 1128 WP_019468109.1 tRNA epoxyqueuosine(34) reductase QueG -
EGX68_RS08075 1584598..1585320 - 723 WP_103211469.1 amino acid ABC transporter ATP-binding protein -
EGX68_RS08080 1585313..1586776 - 1464 WP_019468107.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(131-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7101.46 Da        Isoelectric Point: 3.8967

>T114178 WP_019468112.1 NZ_CP033735:c1582031-1581846 [Staphylococcus cohnii]
MTDDNANKKYSNHEAEPKNEMVDDFEDIVELGKEMEQISEENDEDKLDKSHDSNVRSDLDN

Download         Length: 186 bp

>T114178 NZ_CP033735:c1582031-1581846 [Staphylococcus cohnii]
ATGACAGATGATAATGCAAATAAAAAGTATTCTAACCATGAAGCAGAACCAAAAAATGAAATGGTTGATGATTTTGAAGA
TATCGTAGAATTGGGAAAAGAAATGGAACAAATTTCTGAAGAAAATGATGAAGATAAACTAGATAAATCACATGATTCAA
ATGTACGTTCTGATTTAGATAATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22265.00 Da        Isoelectric Point: 4.9618

>AT114178 WP_019468111.1 NZ_CP033735:c1582655-1582056 [Staphylococcus cohnii]
MAMNFKILENEKSVAEYAADILRKQFNNNPTTIAGIHLSNDNAPVLDELKKNVDDHAVDFSQINILDYDSNKSYFEALGV
PEGQIYGVSYGQDTESFISDKIKTKENKGKLITQILSIDTNGRLNVSINHGLFSAREVILVITGSEKKDVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT114178 NZ_CP033735:c1582655-1582056 [Staphylococcus cohnii]
ATGGCAATGAACTTTAAAATTTTAGAAAACGAAAAAAGTGTAGCAGAATATGCTGCAGATATTTTAAGAAAACAGTTTAA
CAATAATCCAACTACTATAGCAGGCATACATCTTTCTAATGATAATGCACCAGTATTAGATGAATTAAAGAAAAATGTAG
ATGATCATGCAGTAGATTTTAGTCAAATTAATATATTAGATTATGACAGCAATAAGTCTTATTTTGAAGCGTTAGGCGTA
CCAGAAGGTCAAATATATGGTGTTTCATATGGTCAAGATACAGAATCATTTATAAGTGATAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTGATTACACAAATACTGTCAATAGATACAAATGGCAGACTTAATGTAAGTATCAATCATGGTCTCTTTT
CTGCAAGAGAAGTAATTTTAGTGATTACTGGTTCTGAGAAAAAAGATGTTGTGCATAAATTATATGAAGAAAATGGTAAA
ACTTCATTTGAGCCATCTGATTTGAAAGCACACCGTATGGTAAATGTTATTTTGGATGAAGCTGCTGCAGAAGGTCTTCC
TGAAGATGTTCGTCACTATTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2NVX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2NXJ1

References