114177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 605744..606552 Replicon chromosome
Accession NZ_CP033735
Organism Staphylococcus cohnii strain FDAARGOS_538

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EGX68_RS03330 Protein ID WP_103211325.1
Coordinates 605744..606208 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EGX68_RS03335 Protein ID WP_103211324.1
Coordinates 606220..606552 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX68_RS03305 601397..601846 + 450 WP_019469761.1 SUF system NifU family Fe-S cluster assembly protein -
EGX68_RS03310 601974..603371 + 1398 WP_019469760.1 Fe-S cluster assembly protein SufB -
EGX68_RS03315 603440..604498 - 1059 WP_019469759.1 site-specific integrase -
EGX68_RS03320 604743..605108 - 366 Protein_601 hypothetical protein -
EGX68_RS03325 605237..605728 - 492 WP_103211326.1 PH domain-containing protein -
EGX68_RS03330 605744..606208 - 465 WP_103211325.1 toxin Toxin
EGX68_RS03335 606220..606552 - 333 WP_103211324.1 helix-turn-helix domain-containing protein Antitoxin
EGX68_RS03340 606746..606997 + 252 WP_069795256.1 helix-turn-helix domain-containing protein -
EGX68_RS03345 606998..607810 + 813 WP_103211323.1 DUF3102 domain-containing protein -
EGX68_RS03350 607814..608662 + 849 WP_103211322.1 ParB N-terminal domain-containing protein -
EGX68_RS03355 608820..609032 + 213 WP_103211321.1 hypothetical protein -
EGX68_RS03360 609029..609238 - 210 WP_038678654.1 hypothetical protein -
EGX68_RS03365 609315..609521 + 207 WP_103211320.1 hypothetical protein -
EGX68_RS03370 609764..610018 + 255 WP_103211319.1 hypothetical protein -
EGX68_RS03375 610011..610658 + 648 WP_103211318.1 ERF family protein -
EGX68_RS03380 610661..611101 + 441 WP_103211317.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 601974..648092 46118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18235.84 Da        Isoelectric Point: 5.6361

>T114177 WP_103211325.1 NZ_CP033735:c606208-605744 [Staphylococcus cohnii]
MGLYEDLCMANENVEIKETSRLPSFQPGCYINGEIFIKNNISDIRKAEVLFEELGHHEKTYGNILDQSKWINRKFENYAV
RHGYQAALPLRLIIEAYHYGISNLHELAEYVELSEEYIIKVIEFYKKKYGLSTYYKGYVIKFEPLQVFEFKNLD

Download         Length: 465 bp

>T114177 NZ_CP033735:c606208-605744 [Staphylococcus cohnii]
ATGGGGTTATACGAAGATTTATGTATGGCAAACGAAAATGTAGAAATTAAAGAAACCAGTCGCTTACCTAGTTTTCAACC
CGGTTGTTATATAAATGGAGAAATTTTTATAAAAAATAACATATCTGACATTAGAAAAGCAGAAGTGTTATTTGAAGAAT
TAGGTCATCATGAAAAGACATATGGGAATATACTTGACCAGTCTAAATGGATTAACCGTAAATTTGAAAATTACGCAGTA
AGACATGGTTATCAAGCTGCCCTACCATTACGTTTAATTATAGAAGCATATCATTATGGAATAAGTAACTTACACGAGTT
GGCAGAATATGTCGAGTTAAGCGAAGAGTACATAATTAAAGTGATTGAGTTTTATAAAAAGAAATATGGTTTATCCACCT
ATTACAAAGGATACGTAATCAAGTTTGAACCGTTACAAGTATTTGAATTTAAAAATTTAGATTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12833.37 Da        Isoelectric Point: 4.5050

>AT114177 WP_103211324.1 NZ_CP033735:c606552-606220 [Staphylococcus cohnii]
MRTNDEIITVIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFAKALHISTEYLLGFEENEQEQPEQDT
IAAHFDKDGLTEDEIEEVNKFIEWVKNRDK

Download         Length: 333 bp

>AT114177 NZ_CP033735:c606552-606220 [Staphylococcus cohnii]
ATGAGAACAAATGATGAAATAATCACGGTAATTAAAACAACATTAAAAGAACAAAACATGTCACTTAGTGAATTGGCTCG
TCGTGTGGGAATGGCTAAATCCGCTGTATCACGTTATTTAAATTTAACTAGAGAGTTCCCTTTGAATCGTGCAGAAGATT
TTGCTAAAGCACTTCATATTAGTACTGAATATTTACTTGGGTTTGAAGAAAATGAACAAGAACAACCAGAACAAGACACA
ATCGCAGCACATTTTGATAAAGATGGCTTAACAGAAGATGAAATAGAAGAAGTTAATAAATTCATAGAATGGGTTAAGAA
TAGAGATAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References