Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1764888..1765683 Replicon chromosome
Accession NZ_CP033732
Organism Staphylococcus hominis strain FDAARGOS_575

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag EGX58_RS09000 Protein ID WP_002449670.1
Coordinates 1765516..1765683 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag EGX58_RS08995 Protein ID WP_002455147.1
Coordinates 1764888..1765487 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX58_RS08975 1760704..1762158 + 1455 WP_002455144.1 ABC transporter substrate-binding protein/permease -
EGX58_RS08980 1762151..1762873 + 723 WP_002449645.1 amino acid ABC transporter ATP-binding protein -
EGX58_RS08985 1763135..1764256 + 1122 WP_037554399.1 tRNA epoxyqueuosine(34) reductase QueG -
EGX58_RS08990 1764258..1764728 + 471 WP_002455146.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EGX58_RS08995 1764888..1765487 + 600 WP_002455147.1 hypothetical protein Antitoxin
EGX58_RS09000 1765516..1765683 + 168 WP_002449670.1 hypothetical protein Toxin
EGX58_RS09005 1765794..1766186 + 393 WP_002449658.1 hypothetical protein -
EGX58_RS09010 1766325..1767710 + 1386 WP_002455148.1 class II fumarate hydratase -
EGX58_RS09015 1767789..1768613 - 825 WP_002449623.1 RluA family pseudouridine synthase -
EGX58_RS09020 1768751..1769860 + 1110 WP_002455149.1 GAF domain-containing sensor histidine kinase -
EGX58_RS09025 1769875..1770498 + 624 WP_002449659.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6477.82 Da        Isoelectric Point: 4.0410

>T114176 WP_002449670.1 NZ_CP033732:1765516-1765683 [Staphylococcus hominis]
MSKDSKRNYHEDENAMVQNMNDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Download         Length: 168 bp

>T114176 NZ_CP033732:1765516-1765683 [Staphylococcus hominis]
ATGAGTAAAGATAGTAAACGTAATTATCATGAAGACGAAAATGCAATGGTTCAAAATATGAATGATTTAGAAGCATTAGG
AAAAGAAATGGAACAGATTTCTGAAGAAAATGATGAAGATAAATATAATCAAACACATGATTCAGAAGCGCGTTCAGATT
TAAATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22388.31 Da        Isoelectric Point: 5.3510

>AT114176 WP_002455147.1 NZ_CP033732:1764888-1765487 [Staphylococcus hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNTGHLDVNIRQGLMKAREIILVVTGAKKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT114176 NZ_CP033732:1764888-1765487 [Staphylococcus hominis]
ATGGCAATGAATTTTAAAGTATTTGAAGATAAACAACATGCAGCAGATTACGCTGGAGATATTATTAGAAAACAATTTAA
CAATAACCCAACTACCATTGCTGGATTTCATTTAAACAAGGATTCTGCACCTGTATTAGATGAACTAAAAAAATCAGTTG
ATCGTAACGCTGTAGATTTTAGTCAAATTAATATTCTTGATTATGATGATAATCATTCGTTCTATGAAGCTTTAGGTGTA
CCTTCTGAGCAAGTATATTCTATTAGTCTTGATGATGATGCCGAATCATTAATCAATGATAGAATTAAAACAAAGGAAAA
TAAAGGGAAACTGACTTTACAAGTTGTTTCAATCGATAACACTGGACATTTAGATGTTAATATTCGTCAAGGTTTGATGA
AAGCACGTGAAATTATCTTAGTTGTAACTGGTGCTAAAAAAAGTGAAGTTATCAAACGATTATATGAAGAAAATGGTAAA
TCAAACTTTTTACCAGCTGATTTAAAAGTACATCGTATGGTAACAGTTGTTTTAGACAGAGCTGCTGCTGATGGATTACC
AGAAGATGTTAAAGAATACTTCACAGCGAGATTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References