Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1635863..1636392 Replicon chromosome
Accession NZ_CP033732
Organism Staphylococcus hominis strain FDAARGOS_575

Toxin (Protein)


Gene name mazF Uniprot ID A0A4Q9WNP6
Locus tag EGX58_RS08240 Protein ID WP_017174798.1
Coordinates 1636030..1636392 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L8Y5N2
Locus tag EGX58_RS08235 Protein ID WP_002448681.1
Coordinates 1635863..1636033 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX58_RS08210 1631768..1632247 + 480 WP_002448666.1 PH domain-containing protein -
EGX58_RS08215 1632237..1633739 + 1503 WP_037554377.1 PH domain-containing protein -
EGX58_RS08220 1633732..1634208 + 477 WP_065580927.1 PH domain-containing protein -
EGX58_RS08225 1634236..1634589 + 354 WP_002448655.1 holo-ACP synthase -
EGX58_RS08230 1634632..1635777 + 1146 WP_002448692.1 alanine racemase -
EGX58_RS08235 1635863..1636033 + 171 WP_002448681.1 hypothetical protein Antitoxin
EGX58_RS08240 1636030..1636392 + 363 WP_017174798.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EGX58_RS08245 1636764..1637765 + 1002 WP_002448679.1 PP2C family protein-serine/threonine phosphatase -
EGX58_RS08250 1637851..1638177 + 327 WP_002448686.1 anti-sigma factor antagonist -
EGX58_RS08255 1638179..1638658 + 480 WP_002448683.1 anti-sigma B factor RsbW -
EGX58_RS08260 1638633..1639403 + 771 WP_002455074.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13580.74 Da        Isoelectric Point: 9.8760

>T114175 WP_017174798.1 NZ_CP033732:1636030-1636392 [Staphylococcus hominis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDDALDISLGLHDVRPQKN

Download         Length: 363 bp

>T114175 NZ_CP033732:1636030-1636392 [Staphylococcus hominis]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTAATCGTTGCTGCGATTACTGGCAGGATTAATAAAGCGA
AAATACCAACACATGTAGAAATAGAAAAGAAAAAATATCGTTTAGATAAAGATTCAGTCATTCTTTTAGAACAAATACGA
ACATTGGATAAAAAAAGGTTGAAAGAGAAACTTACATATTTATCAGAAGATAAAATGAAAGAAGTTGACGATGCATTGGA
TATCAGTTTAGGTTTACACGATGTTCGTCCTCAAAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6368.03 Da        Isoelectric Point: 4.0121

>AT114175 WP_002448681.1 NZ_CP033732:1635863-1636033 [Staphylococcus hominis]
MLTFNQNRSHSLEQSLKEGYVQMADLNLSLATEAFPLECEACDCNESYLTSNYKSE

Download         Length: 171 bp

>AT114175 NZ_CP033732:1635863-1636033 [Staphylococcus hominis]
ATGTTAACTTTTAATCAGAATAGAAGCCATAGTCTTGAACAATCACTAAAAGAAGGCTATGTCCAAATGGCCGATTTAAA
CCTCTCCCTAGCAACTGAAGCATTTCCATTAGAATGTGAAGCTTGTGATTGTAACGAATCTTATCTTACATCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q9WNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5N2

References