114174

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1624848..1625366 Replicon chromosome
Accession NZ_CP033732
Organism Staphylococcus hominis strain FDAARGOS_575

Toxin (Protein)


Gene name TsdT Uniprot ID A0A6B8SK15
Locus tag EGX58_RS08180 Protein ID WP_002448674.1
Coordinates 1625157..1625366 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag EGX58_RS08175 Protein ID WP_002437530.1
Coordinates 1624848..1625141 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX58_RS08150 1620071..1620859 + 789 WP_002448660.1 hydroxyethylthiazole kinase -
EGX58_RS08155 1620862..1621500 + 639 WP_002448695.1 thiamine phosphate synthase -
EGX58_RS08160 1621589..1622458 + 870 WP_002455066.1 membrane protein insertase YidC -
EGX58_RS08165 1622516..1623163 - 648 WP_002448635.1 HD domain-containing protein -
EGX58_RS08170 1623198..1624682 - 1485 WP_103288309.1 cardiolipin synthase -
EGX58_RS08175 1624848..1625141 + 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
EGX58_RS08180 1625157..1625366 + 210 WP_002448674.1 heavy-metal-associated domain-containing protein Toxin
EGX58_RS08185 1625479..1625616 + 138 WP_002437525.1 hypothetical protein -
EGX58_RS08190 1625777..1626961 - 1185 WP_002455068.1 rod shape-determining protein RodA -
EGX58_RS08195 1627335..1628405 + 1071 WP_002455069.1 D-alanine--D-alanine ligase -
EGX58_RS08200 1628421..1629776 + 1356 WP_002455070.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7956.00 Da        Isoelectric Point: 4.0857

>T114174 WP_002448674.1 NZ_CP033732:1625157-1625366 [Staphylococcus hominis]
MLNSNIVFIDNIETEEQAQMLNERLLNMIGVHTVSIDIERNKINVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T114174 NZ_CP033732:1625157-1625366 [Staphylococcus hominis]
ATGTTAAACAGTAATATTGTATTTATAGATAACATTGAAACAGAAGAACAAGCACAAATGTTAAATGAACGTTTGTTAAA
TATGATTGGAGTACATACGGTATCAATCGATATAGAAAGAAATAAGATTAATGTTGAATATGAAACACCTACTAATTTAA
ATAGTATTGAAAAAGAAATTTATGACGCTGGATTTAAAGTACTTTCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT114174 WP_002437530.1 NZ_CP033732:1624848-1625141 [Staphylococcus hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT114174 NZ_CP033732:1624848-1625141 [Staphylococcus hominis]
TTGGAAAATCAAAATCATGCCCATCATTCTGAGCAAGTTAAATTAAATTTAAAATCTCGATTAAATCGAATAGAAGGACA
AGTTAAAGCAATTAATCGAATGATTGATGAAGACGTCTACTGTGATGATGTATTAACTCAGATAAGAGCAACACGTTCAG
CACTTAATAGTGTTGCTACTAAGTTACTAGAACATCACATGAAAAGTTGTATTATGGAAAAAATAAATCAAGGTACTGAA
GAAGAAGCAATGGAAGAACTACTAGTGACATTTCAAAAACTAGTGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B8SK15

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References