Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 558300..559966 Replicon chromosome
Accession NZ_CP033730
Organism Achromobacter denitrificans strain PheN1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag EC609_RS02560 Protein ID WP_123785925.1
Coordinates 558300..559139 (+) Length 280 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag EC609_RS02565 Protein ID WP_062683047.1
Coordinates 559151..559966 (+) Length 272 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC609_RS02535 553820..554578 - 759 WP_123785922.1 ABC transporter permease -
EC609_RS02540 554580..555368 - 789 WP_075873250.1 ABC transporter ATP-binding protein -
EC609_RS02545 555501..556361 - 861 WP_123785923.1 ABC transporter substrate-binding protein -
EC609_RS02550 556407..556997 - 591 WP_062683070.1 cupin domain-containing protein -
EC609_RS02555 557092..558147 - 1056 WP_123785924.1 porin -
EC609_RS02560 558300..559139 + 840 WP_123785925.1 alpha/beta hydrolase Toxin
EC609_RS02565 559151..559966 + 816 WP_062683047.1 IclR family transcriptional regulator Antitoxin
EC609_RS02570 560028..560819 + 792 WP_123785926.1 SDR family oxidoreductase -
EC609_RS02575 560812..562482 + 1671 WP_123785927.1 thiamine pyrophosphate-binding protein -
EC609_RS02580 562490..563287 + 798 WP_088148634.1 aspartate dehydrogenase -
EC609_RS02585 563295..564782 + 1488 WP_123785928.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(39-270)

Antitoxin

Transcription regulator IclR, C-terminal

(138-260)


Sequences

Toxin        


Download         Length: 280 a.a.        Molecular weight: 29123.24 Da        Isoelectric Point: 7.8874

>T114171 WP_123785925.1 NZ_CP033730:558300-559139 [Achromobacter denitrificans]
MPATEQAMRDQALHRFTACLAPTAQGPSAYRRLGTGPAVVLLHGIGSGSGCWLDAATALAGECTVLAWDAPGYGASAPLA
GDRPSAADYAERLHQVLRHAGIDECVLVGHSLGALVAAAYCARRERARISRLVLLSPARGYGSADAGEREATRGKRLGAL
ERLGIDGMAAARASALLSPAAQAGQVQWAAWNMRQITPEGYRQAVGLLCDGDLLAFPAPPMSVDVRVGIHDTITPAPKCQ
AIAAAWRASFELIPGAGHACHIERPQEVAEIVRQARAGS

Download         Length: 840 bp

>T114171 NZ_CP033730:558300-559139 [Achromobacter denitrificans]
ATGCCCGCTACCGAGCAAGCCATGCGCGATCAGGCGCTGCATCGCTTTACCGCCTGCCTGGCTCCCACCGCGCAGGGCCC
GTCGGCCTACCGCCGGCTGGGCACGGGGCCGGCCGTCGTTTTGCTGCATGGCATCGGCTCGGGATCGGGCTGCTGGCTCG
ACGCCGCGACGGCGCTTGCCGGGGAATGCACGGTCTTGGCCTGGGACGCGCCGGGCTATGGCGCGTCGGCGCCGCTGGCC
GGGGATCGGCCTTCGGCTGCCGACTACGCGGAACGGCTGCACCAGGTCCTGCGCCACGCCGGCATCGACGAATGCGTGCT
GGTCGGCCATTCGCTGGGCGCGCTCGTAGCGGCGGCCTATTGCGCGCGGCGGGAACGGGCGCGGATCTCGCGCCTGGTCT
TGCTGAGCCCCGCGCGCGGCTATGGGTCGGCCGACGCGGGCGAACGCGAGGCCACGCGCGGCAAGCGCCTGGGCGCGCTC
GAACGCCTGGGCATCGACGGCATGGCGGCGGCCCGCGCCAGCGCCCTGCTGTCGCCGGCGGCGCAGGCCGGGCAGGTGCA
ATGGGCCGCCTGGAACATGCGGCAGATCACCCCGGAGGGCTATCGCCAGGCCGTGGGGCTGCTGTGCGACGGCGACCTGC
TGGCCTTCCCCGCCCCGCCCATGTCCGTGGATGTGCGGGTGGGGATTCATGACACCATTACGCCTGCGCCAAAGTGCCAG
GCAATCGCCGCGGCATGGCGGGCATCGTTTGAGCTAATCCCCGGGGCGGGCCATGCCTGCCATATCGAGCGGCCGCAGGA
GGTCGCCGAAATCGTGCGCCAGGCGCGCGCCGGTTCCTGA

Antitoxin


Download         Length: 272 a.a.        Molecular weight: 29497.47 Da        Isoelectric Point: 6.0246

>AT114171 WP_062683047.1 NZ_CP033730:559151-559966 [Achromobacter denitrificans]
MSDTDVNDDGRDRYTVPALERGLRLLCQFNRNDRALGAPELARRLDLPRSTVFRMLNTLEHMGFVRKTDGGSTYQLDMGV
LRLGFEYLASLELTELGRPLLERVRDATGYPSNLVVLDQHWAVVVAKSSAPTPFVSTVYVGTRLPAHATLLGRALLCDLS
LDALRNLYGDAPLQSYSPRTPGTVEALHEVLQQDRARGYVSDHGFYEAAVASIAAPVRDRNGATVAALGVTIPTMTTTQP
AMDEAGVIATVRSAADELSRLLDYAPPGATR

Download         Length: 816 bp

>AT114171 NZ_CP033730:559151-559966 [Achromobacter denitrificans]
ATGAGTGACACCGATGTGAATGACGACGGTCGCGACCGCTACACCGTCCCCGCGCTGGAGCGCGGCCTGCGCCTGCTGTG
CCAGTTCAACCGCAACGACCGCGCGCTGGGCGCGCCCGAACTGGCGCGCCGGCTCGACCTCCCCCGGTCGACCGTGTTCC
GCATGCTCAATACGCTGGAGCACATGGGCTTCGTGCGCAAGACCGACGGCGGCTCCACCTACCAGCTGGACATGGGCGTG
CTCCGCCTGGGCTTCGAGTACCTGGCCTCGCTGGAACTGACGGAGCTCGGCCGCCCCTTGCTGGAACGCGTGCGCGACGC
CACCGGCTACCCCTCCAACCTGGTGGTGCTGGACCAGCACTGGGCCGTGGTGGTGGCCAAATCGTCCGCGCCCACCCCTT
TCGTCAGCACGGTCTACGTCGGCACCCGCCTGCCGGCGCATGCCACCTTGCTGGGCCGCGCCCTGCTCTGCGACCTGAGC
CTGGACGCGCTGCGGAATCTCTATGGCGACGCGCCGCTGCAAAGCTATTCGCCGCGCACGCCGGGCACGGTGGAAGCGCT
GCACGAGGTGCTGCAGCAGGACCGCGCGCGCGGCTACGTGAGCGATCACGGCTTCTATGAGGCCGCCGTCGCCAGCATCG
CCGCCCCCGTGCGCGATCGCAACGGCGCCACCGTGGCCGCGCTGGGCGTGACGATACCGACGATGACCACCACGCAGCCG
GCCATGGACGAAGCGGGCGTGATCGCCACCGTGCGCAGCGCGGCCGACGAGTTGTCGCGCTTACTGGATTACGCGCCACC
CGGCGCGACGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References