Detailed information of TA system TA114167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 845966..846482
• Replicon: chromosome
• Accession: NZ_CP033719
• Organism: Propionibacterium acidifaciens strain FDAARGOS_576

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: U2PYI5
• Locus tag: EGX94_RS03585
• Protein ID: WP_021797569.1
• Coordinates: 845966..846220 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2RY89
• Locus tag: EGX94_RS03590
• Protein ID: WP_021797566.1
• Coordinates: 846222..846482 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX94_RS03570	841760..842662	+	903	WP_021796964.1	aldo/keto reductase	-
EGX94_RS03575	842659..844794	+	2136	WP_123825907.1	hypothetical protein	-
EGX94_RS03580	845036..845680	-	645	WP_021797564.1	class I SAM-dependent methyltransferase	-
EGX94_RS03585	845966..846220	-	255	WP_021797569.1	Txe/YoeB family addiction module toxin	Toxin
EGX94_RS03590	846222..846482	-	261	WP_021797566.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EGX94_RS03595	846625..847716	-	1092	WP_021797565.1	redox-regulated ATPase YchF	-
EGX94_RS03600	847757..849019	-	1263	WP_043121620.1	M18 family aminopeptidase	-
EGX94_RS03605	849165..850412	+	1248	WP_021797570.1	DNA recombination protein RmuC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	835444..846482	11038

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-66)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10043.38 Da
• Isoelectric Point: 6.2171

>T114167 WP_021797569.1 NZ_CP033719:c846220-845966 [Propionibacterium acidifaciens]
MRLVWVDSAWEDYEHWQTADRKILKRVNTLIDACLRDPFDGIGRPEQLRYGAPGAWSRRITEEHRLVYLVDGDDLIILQA
RYHY

Nucleotide

• Length: 255 bp

>T114167 NZ_CP033719:c846220-845966 [Propionibacterium acidifaciens]
ATGCGCCTGGTCTGGGTCGATTCTGCGTGGGAGGACTACGAGCACTGGCAAACGGCTGACCGCAAGATCCTCAAGCGTGT
CAACACGCTGATCGACGCATGCCTGCGCGACCCATTCGACGGCATCGGCAGACCGGAACAACTCAGATACGGCGCGCCGG
GCGCGTGGTCTCGGCGCATCACGGAGGAGCATCGTCTGGTCTACCTCGTCGACGGCGATGATCTGATCATCCTGCAGGCG
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9628.71 Da
• Isoelectric Point: 4.6768

>AT114167 WP_021797566.1 NZ_CP033719:c846482-846222 [Propionibacterium acidifaciens]
MSISASEARRTLFPLIERVNADRDAVEIVSRHGNAVLMPADEYAEWQETAYLFRSPANARRLLDACERARGGEVVVHELD
RSGEDA

Nucleotide

• Length: 261 bp

>AT114167 NZ_CP033719:c846482-846222 [Propionibacterium acidifaciens]
ATGTCGATCAGTGCCAGTGAGGCTCGCAGGACACTGTTCCCGCTCATCGAGCGGGTGAATGCGGATCGTGATGCGGTCGA
GATCGTTTCTCGTCATGGCAATGCCGTCCTGATGCCCGCCGATGAGTACGCGGAATGGCAGGAGACGGCCTACCTGTTCC
GCTCTCCGGCCAATGCCCGTCGTCTGCTGGACGCTTGCGAGCGCGCCCGGGGCGGTGAGGTTGTCGTGCATGAACTCGAT
CGATCGGGTGAGGACGCCTGA

Structures

Toxin

• AlphaFold DB: U2PYI5

Antitoxin

• AlphaFold DB: U2RY89