Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1513896..1514672 Replicon chromosome
Accession NZ_CP033717
Organism Yersinia pseudotuberculosis strain FDAARGOS_579

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H3B6R1
Locus tag EGX53_RS07620 Protein ID WP_012304462.1
Coordinates 1513896..1514279 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H3B780
Locus tag EGX53_RS07625 Protein ID WP_012304463.1
Coordinates 1514343..1514672 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX53_RS07590 1509942..1510352 - 411 WP_123767129.1 hypothetical protein -
EGX53_RS07600 1510523..1510852 + 330 WP_050756398.1 hypothetical protein -
EGX53_RS07605 1511023..1512177 + 1155 WP_012304459.1 site-specific integrase -
EGX53_RS07610 1512381..1513229 - 849 WP_012304460.1 DUF4942 domain-containing protein -
EGX53_RS07615 1513404..1513899 - 496 Protein_1339 hypothetical protein -
EGX53_RS07620 1513896..1514279 - 384 WP_012304462.1 TA system toxin CbtA family protein Toxin
EGX53_RS07625 1514343..1514672 - 330 WP_012304463.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EGX53_RS07630 1514685..1515155 - 471 WP_012304464.1 DNA repair protein RadC -
EGX53_RS07635 1515226..1516047 - 822 WP_012304465.1 DUF945 domain-containing protein -
EGX53_RS07640 1516136..1516474 - 339 WP_012304466.1 hypothetical protein -
EGX53_RS07645 1516495..1516959 - 465 WP_012304467.1 hypothetical protein -
EGX53_RS07660 1517460..1518347 - 888 WP_012304468.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14442.40 Da        Isoelectric Point: 8.9291

>T114164 WP_012304462.1 NZ_CP033717:c1514279-1513896 [Yersinia pseudotuberculosis]
MQTLPVNPKRAAQTCPSPVEIWQKLLTHLLDQHYGLTLSDTSFSNETTIREHIDAGISLSYAVNFLVEKYELVRTDRTSF
TIVEQSPFITPIDILRARQATGLLKRSGYKAVSDITRGRARREEQSH

Download         Length: 384 bp

>T114164 NZ_CP033717:c1514279-1513896 [Yersinia pseudotuberculosis]
ATGCAAACCTTACCCGTAAACCCGAAACGGGCGGCACAAACCTGCCCGTCACCTGTTGAAATATGGCAAAAACTGCTAAC
GCATCTGCTCGATCAACACTATGGACTCACACTTAGTGATACCTCGTTCAGCAATGAAACCACCATCCGTGAACATATTG
ACGCCGGAATATCCCTCAGCTATGCGGTGAACTTCCTGGTGGAAAAATATGAACTGGTACGCACTGACCGGACCAGTTTC
ACCATTGTGGAGCAATCACCGTTTATCACCCCAATCGATATTCTCCGCGCCAGGCAAGCCACCGGTCTCCTGAAGCGCAG
TGGTTATAAAGCCGTCAGTGACATTACCCGTGGCAGAGCTCGGCGAGAGGAGCAAAGCCATTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12234.84 Da        Isoelectric Point: 6.4825

>AT114164 WP_012304463.1 NZ_CP033717:c1514672-1514343 [Yersinia pseudotuberculosis]
MSLTLSHEWGLKSDITPRFGARLVQEGNRLHFRADHAGFNGAFSEDEALRLDQAFPLMLKQLELKLLSGELNPRRQHCVT
LNHNGLTCEADTLGSHGYVYITIYPASPE

Download         Length: 330 bp

>AT114164 NZ_CP033717:c1514672-1514343 [Yersinia pseudotuberculosis]
ATGTCATTAACACTATCCCATGAATGGGGGCTAAAAAGCGATATCACCCCACGCTTTGGCGCAAGATTGGTGCAGGAAGG
CAATCGCCTGCACTTTCGGGCTGACCATGCGGGTTTTAACGGTGCATTCAGTGAGGATGAGGCGCTGCGGCTTGACCAAG
CGTTTCCACTGATGCTCAAACAGCTTGAACTTAAGCTGCTATCCGGTGAGCTCAATCCTCGTCGTCAGCATTGCGTTACG
TTGAACCACAATGGCCTGACCTGCGAAGCTGACACCCTCGGCTCTCACGGGTATGTCTATATCACTATTTACCCGGCAAG
CCCGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3B6R1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3B780

References