Detailed information of TA system TA114153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 4550671..4551317
• Replicon: chromosome
• Accession: NZ_CP033715
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_580

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2A7VEB5
• Locus tag: EGX52_RS21615
• Protein ID: WP_050105361.1
• Coordinates: 4550671..4550853 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A2A7VE79
• Locus tag: EGX52_RS21620
• Protein ID: WP_042592976.1
• Coordinates: 4550898..4551317 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX52_RS21580	4545924..4547123	-	1200	WP_098087203.1	hypothetical protein	-
EGX52_RS21585	4547107..4547466	-	360	WP_057532700.1	hypothetical protein	-
EGX52_RS21590	4547463..4548140	-	678	WP_042592987.1	hypothetical protein	-
EGX52_RS21595	4548122..4548961	-	840	WP_098087202.1	hypothetical protein	-
EGX52_RS21600	4548965..4549267	-	303	WP_012105513.1	hypothetical protein	-
EGX52_RS21605	4549269..4549697	-	429	Protein_3923	hypothetical protein	-
EGX52_RS21610	4549693..4550568	-	876	Protein_3924	TerL protein	-
EGX52_RS21615	4550671..4550853	+	183	WP_050105361.1	type II toxin-antitoxin system HicA family toxin	Toxin
EGX52_RS21620	4550898..4551317	+	420	WP_042592976.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EGX52_RS21625	4551598..4552203	-	606	WP_072193999.1	terminase small subunit	-
EGX52_RS21630	4552631..4552969	+	339	WP_057532504.1	hypothetical protein	-
EGX52_RS21635	4552966..4553637	+	672	WP_057532500.1	hypothetical protein	-
EGX52_RS23545	4553868..4554026	+	159	WP_098087225.1	hypothetical protein	-
EGX52_RS21645	4554065..4554307	+	243	WP_038401413.1	excisionase	-
EGX52_RS21650	4554291..4555415	+	1125	WP_038401411.1	phage integrase Arm DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4541165..4557549	16384

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-131)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6811.02 Da
• Isoelectric Point: 11.0775

>T114153 WP_050105361.1 NZ_CP033715:4550671-4550853 [Yersinia pseudotuberculosis]
VKSSELIKRLEANGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDIKPGTLRQILKDANLS

Nucleotide

• Length: 183 bp

>T114153 NZ_CP033715:4550671-4550853 [Yersinia pseudotuberculosis]
GTGAAAAGTTCGGAGCTGATAAAACGACTCGAAGCAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCAAAGAAGGACATTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15448.21 Da
• Isoelectric Point: 4.7791

>AT114153 WP_042592976.1 NZ_CP033715:4550898-4551317 [Yersinia pseudotuberculosis]
MAIYPAYVHVDSDGSASGYFPDVKGCIFAIDAGEDLFAEASSALEAHFEALVSEGIEIPEAHDMPFHYHTNPSNYSDGGQ
WYNVSIDMSKYDGKAERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Nucleotide

• Length: 420 bp

>AT114153 NZ_CP033715:4550898-4551317 [Yersinia pseudotuberculosis]
ATGGCTATCTATCCCGCATACGTTCATGTCGATAGTGATGGCTCGGCAAGCGGTTATTTCCCTGACGTCAAAGGCTGTAT
TTTTGCCATTGATGCCGGAGAGGATTTATTTGCAGAGGCATCAAGCGCCCTGGAGGCGCACTTTGAGGCGTTGGTGTCTG
AGGGTATTGAGATACCCGAGGCGCATGATATGCCTTTCCACTACCACACCAATCCGAGCAATTACAGTGACGGCGGCCAG
TGGTATAACGTGAGTATTGATATGTCAAAATATGACGGAAAAGCCGAGCGGATTAACGTCACTCTTCCTCACCGGCTGAT
CCATCAAATCGATACCATTGTTAAGGTGCGTCCAGAGTACGCCAGCCGGAGTAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTAGCGTAA

Structures

Toxin

• AlphaFold DB: A0A2A7VEB5

Antitoxin

• AlphaFold DB: A0A2A7VE79