Detailed information of TA system TA114152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 4299254..4300220
• Replicon: chromosome
• Accession: NZ_CP033715
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_580

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: EGX52_RS20290
• Protein ID: WP_011192520.1
• Coordinates: 4299762..4300220 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: EGX52_RS20285
• Protein ID: WP_002210982.1
• Coordinates: 4299254..4299700 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX52_RS20265	4294786..4295493	+	708	WP_002220315.1	murein tripeptide amidase MpaA	-
EGX52_RS20270	4295552..4296526	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
EGX52_RS20275	4296689..4297192	+	504	WP_057532365.1	thiol peroxidase	-
EGX52_RS20280	4297339..4298916	-	1578	WP_050320587.1	transcriptional regulator TyrR	-
EGX52_RS20285	4299254..4299700	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
EGX52_RS20290	4299762..4300220	+	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
EGX52_RS20295	4300230..4301291	-	1062	WP_050320586.1	YcjF family protein	-
EGX52_RS20300	4301288..4302685	-	1398	WP_057532366.1	YcjX family protein	-
EGX52_RS20305	4302666..4302908	-	243	WP_080987533.1	phage shock protein PspD	-
EGX52_RS20310	4302993..4303352	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
EGX52_RS20315	4303352..4303579	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
EGX52_RS20320	4303741..4304406	-	666	WP_011192521.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T114152 WP_011192520.1 NZ_CP033715:4299762-4300220 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T114152 NZ_CP033715:4299762-4300220 [Yersinia pseudotuberculosis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT114152 WP_002210982.1 NZ_CP033715:4299254-4299700 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT114152 NZ_CP033715:4299254-4299700 [Yersinia pseudotuberculosis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTAGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1