Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2927346..2927966 Replicon chromosome
Accession NZ_CP033715
Organism Yersinia pseudotuberculosis strain FDAARGOS_580

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag EGX52_RS14005 Protein ID WP_002208622.1
Coordinates 2927346..2927549 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag EGX52_RS14010 Protein ID WP_002218472.1
Coordinates 2927598..2927966 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX52_RS13970 2922347..2922685 + 339 WP_002208627.1 P-II family nitrogen regulator -
EGX52_RS13975 2922725..2924014 + 1290 WP_002228344.1 ammonium transporter AmtB -
EGX52_RS13980 2924276..2925136 - 861 WP_002208625.1 acyl-CoA thioesterase II -
EGX52_RS13985 2925393..2925914 + 522 WP_050320356.1 YbaY family lipoprotein -
EGX52_RS13990 2926050..2926439 - 390 WP_002208623.1 MGMT family protein -
EGX52_RS14005 2927346..2927549 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
EGX52_RS14010 2927598..2927966 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
EGX52_RS14015 2928125..2928478 - 354 WP_002208619.1 hypothetical protein -
EGX52_RS14020 2929352..2929495 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
EGX52_RS14025 2929511..2929771 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T114142 WP_002208622.1 NZ_CP033715:c2927549-2927346 [Yersinia pseudotuberculosis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T114142 NZ_CP033715:c2927549-2927346 [Yersinia pseudotuberculosis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT114142 WP_002218472.1 NZ_CP033715:c2927966-2927598 [Yersinia pseudotuberculosis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT114142 NZ_CP033715:c2927966-2927598 [Yersinia pseudotuberculosis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References