Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2348025..2348573 Replicon chromosome
Accession NZ_CP033715
Organism Yersinia pseudotuberculosis strain FDAARGOS_580

Toxin (Protein)


Gene name relE Uniprot ID A0A3G5KNV7
Locus tag EGX52_RS11405 Protein ID WP_072080376.1
Coordinates 2348277..2348573 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3G5KKQ2
Locus tag EGX52_RS11400 Protein ID WP_050090618.1
Coordinates 2348025..2348273 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX52_RS11355 2343254..2344087 + 834 WP_057532449.1 DUF945 domain-containing protein -
EGX52_RS11360 2344099..2344322 + 224 Protein_2001 DUF905 domain-containing protein -
EGX52_RS11365 2344397..2344867 + 471 WP_057532450.1 antirestriction protein -
EGX52_RS11370 2344877..2345350 + 474 WP_050090624.1 DNA repair protein RadC -
EGX52_RS11375 2345360..2345581 + 222 WP_050090623.1 DUF987 domain-containing protein -
EGX52_RS11380 2345613..2345981 + 369 WP_050090622.1 type IV toxin-antitoxin system YeeU family antitoxin -
EGX52_RS11385 2346036..2346419 + 384 WP_057532451.1 TA system toxin CbtA family protein -
EGX52_RS11390 2346416..2346907 + 492 WP_050090620.1 hypothetical protein -
EGX52_RS23430 2346921..2347082 - 162 WP_155407244.1 hypothetical protein -
EGX52_RS11395 2347081..2347929 + 849 WP_057532452.1 DUF4942 domain-containing protein -
EGX52_RS11400 2348025..2348273 + 249 WP_050090618.1 ribbon-helix-helix domain-containing protein Antitoxin
EGX52_RS11405 2348277..2348573 + 297 WP_072080376.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGX52_RS11410 2348911..2350146 + 1236 WP_072091827.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2332580..2348573 15993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11801.13 Da        Isoelectric Point: 6.0793

>T114141 WP_072080376.1 NZ_CP033715:2348277-2348573 [Yersinia pseudotuberculosis]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLIIGTSGLADHPRIGVSQTRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDRLSSSSSR

Download         Length: 297 bp

>T114141 NZ_CP033715:2348277-2348573 [Yersinia pseudotuberculosis]
ATGGAAATACAGTGGACCCAAAAGGCCCAAGATGACTTGGAGCGTATTTATAGGTTTGCCTGTCAGTACAGTCGGCAACA
TGCTGACAACGTATTAGAACGTTTGATCATAGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTATCTCAGACAA
GATATGAGCCGCGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATTTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTTAAGTTCGTCATCTTCCAGGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9107.51 Da        Isoelectric Point: 8.7560

>AT114141 WP_050090618.1 NZ_CP033715:2348025-2348273 [Yersinia pseudotuberculosis]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDGGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT114141 NZ_CP033715:2348025-2348273 [Yersinia pseudotuberculosis]
ATGAGACAACTAGCGAAACAGACGATCAGTGCTCAGATCCCTGCAGAGCTTGCTGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCCAAAAGCTGGGTGATTAAGGAAGCGTTAACCGCCATGATTGAAGAGAGAGAGCGGCGTCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGGGGGAAGGGTGGTTAGCCATGCGGATGTGGTTGACTTCGCTAACAAACTGAAA
AAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5KNV7

Antitoxin

Source ID Structure
AlphaFold DB A0A3G5KKQ2

References