Detailed information of TA system TA114139

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1828076..1828832
• Replicon: chromosome
• Accession: NZ_CP033715
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_580

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A3G5KDU1
• Locus tag: EGX52_RS08970
• Protein ID: WP_032467110.1
• Coordinates: 1828464..1828832 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: Q664A5
• Locus tag: EGX52_RS08965
• Protein ID: WP_011193303.1
• Coordinates: 1828076..1828411 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX52_RS08935	1823770..1824063	+	294	Protein_1553	ATP-binding protein	-
EGX52_RS08940	1824117..1824752	+	636	WP_098087291.1	hypothetical protein	-
EGX52_RS08945	1825127..1826214	+	1088	WP_098087213.1	IS3 family transposase	-
EGX52_RS08950	1826239..1826754	+	516	WP_050321080.1	hypothetical protein	-
EGX52_RS08955	1826782..1827402	+	621	WP_011193305.1	hypothetical protein	-
EGX52_RS08960	1827585..1828064	+	480	WP_011193304.1	hypothetical protein	-
EGX52_RS08965	1828076..1828411	+	336	WP_011193303.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EGX52_RS08970	1828464..1828832	+	369	WP_032467110.1	TA system toxin CbtA family protein	Toxin
EGX52_RS08975	1829059..1829913	+	855	WP_032467109.1	DUF4942 domain-containing protein	-
EGX52_RS08980	1830276..1830548	+	273	WP_011193300.1	Arm DNA-binding domain-containing protein	-
EGX52_RS08985	1830783..1831190	+	408	WP_011193299.1	hypothetical protein	-
EGX52_RS08990	1831213..1831539	+	327	WP_011193298.1	hypothetical protein	-
EGX52_RS08995	1831481..1831981	+	501	WP_050117508.1	virulence RhuM family protein	-
EGX52_RS09000	1831978..1832736	-	759	WP_002209584.1	ABC transporter ATP-binding protein	-
EGX52_RS09005	1832733..1833740	-	1008	WP_011193296.1	iron chelate uptake ABC transporter family permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13723.81 Da
• Isoelectric Point: 6.4530

>T114139 WP_032467110.1 NZ_CP033715:1828464-1828832 [Yersinia pseudotuberculosis]
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT

Nucleotide

• Length: 369 bp

>T114139 NZ_CP033715:1828464-1828832 [Yersinia pseudotuberculosis]
ATGCAGATCTTACCTGTCACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12452.06 Da
• Isoelectric Point: 6.0555

>AT114139 WP_011193303.1 NZ_CP033715:1828076-1828411 [Yersinia pseudotuberculosis]
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA

Nucleotide

• Length: 336 bp

>AT114139 NZ_CP033715:1828076-1828411 [Yersinia pseudotuberculosis]
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA

Structures

Toxin

• AlphaFold DB: A0A3G5KDU1

Antitoxin

• AlphaFold DB: Q664A5