Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-CC2985 |
| Location | 53990..54524 | Replicon | plasmid unnamed |
| Accession | NZ_CP033714 | ||
| Organism | Yersinia pseudotuberculosis strain FDAARGOS_580 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | EGX52_RS00380 | Protein ID | WP_057532641.1 |
| Coordinates | 54225..54524 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q9ZGW3 |
| Locus tag | EGX52_RS00375 | Protein ID | WP_002224342.1 |
| Coordinates | 53990..54232 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EGX52_RS00340 | 49891..51057 | + | 1167 | WP_002220902.1 | plasmid-partitioning protein SopA | - |
| EGX52_RS00345 | 51054..52019 | + | 966 | WP_002213354.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| EGX52_RS23310 | 52179..52415 | + | 237 | WP_155490924.1 | hypothetical protein | - |
| EGX52_RS00360 | 52838..53296 | + | 459 | WP_025470851.1 | IS200/IS605-like element IS1541A family transposase | - |
| EGX52_RS00370 | 53532..53824 | + | 293 | Protein_67 | IS6 family transposase | - |
| EGX52_RS00375 | 53990..54232 | + | 243 | WP_002224342.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| EGX52_RS00380 | 54225..54524 | + | 300 | WP_057532641.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EGX52_RS00385 | 54664..55323 | - | 660 | WP_072186775.1 | type III secretion system effector GTPase activator YopE | - |
| EGX52_RS00390 | 55517..55909 | + | 393 | WP_002213403.1 | type III secretion system chaperone SycE/YerA | - |
| EGX52_RS00395 | 55972..56616 | - | 645 | Protein_72 | IS3 family transposase | - |
| EGX52_RS00400 | 56719..57891 | + | 1173 | WP_057532639.1 | IS21 family transposase | - |
| EGX52_RS00405 | 57891..58289 | + | 399 | Protein_74 | ATP-binding protein | - |
| EGX52_RS00410 | 58667..59092 | + | 426 | WP_002213267.1 | type III secretion system chaperone SycH | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | yopO/ypkA / yopJ/yopP / yopH / lcrQ/yscM / yscL / yscK / ylpB/yscJ / lcrO/yscI / yopR/yscH/lcrP / yscG / yscF / yscE / yscD / yscC / yscB / virG/yscW / yscU / yscT / yscS / yscR / yscQ / yscP / yscO / yscN / lcrE/yopN / tyeA / sycN / yscX / yscY / yscV/lcrD / lcrR / lcrG / lcrV / sycD/lcrH / yopB / yopD / yopM / sycT / yopT / yopK/yopQ / yopE / sycE/yerA / sycH / yadA | 1..70312 | 70312 | |
| - | inside | IScluster/Tn | - | yopE / sycE/yerA / sycH / yadA | 46228..68318 | 22090 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11651.23 Da Isoelectric Point: 5.5616
>T114135 WP_057532641.1 NZ_CP033714:54225-54524 [Yersinia pseudotuberculosis]
VYKLSELADEDIYNIASYTIRRFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE
VYKLSELADEDIYNIASYTIRRFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE
Download Length: 300 bp
>T114135 NZ_CP033714:54225-54524 [Yersinia pseudotuberculosis]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCGTTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCGTTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8865.15 Da Isoelectric Point: 6.4781
>AT114135 WP_002224342.1 NZ_CP033714:53990-54232 [Yersinia pseudotuberculosis]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
Download Length: 243 bp
>AT114135 NZ_CP033714:53990-54232 [Yersinia pseudotuberculosis]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|