Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4075672..4076344 Replicon chromosome
Accession NZ_CP033711
Organism Yersinia pseudotuberculosis strain FDAARGOS_582

Toxin (Protein)


Gene name cptA Uniprot ID A0A0U1R236
Locus tag EGX44_RS19415 Protein ID WP_012104676.1
Coordinates 4075919..4076344 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag EGX44_RS19410 Protein ID WP_002209939.1
Coordinates 4075672..4075938 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX44_RS19390 4071512..4072615 + 1104 WP_012413926.1 hypothetical protein -
EGX44_RS19395 4072817..4073518 + 702 WP_012413925.1 hemolysin III family protein -
EGX44_RS19400 4073793..4074290 + 498 WP_002209941.1 DUF2165 family protein -
EGX44_RS19405 4074363..4075355 - 993 WP_012413924.1 tRNA-modifying protein YgfZ -
EGX44_RS19410 4075672..4075938 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
EGX44_RS19415 4075919..4076344 + 426 WP_012104676.1 protein YgfX Toxin
EGX44_RS19420 4076344..4077042 + 699 WP_002209937.1 two-component system response regulator CreB -
EGX44_RS19425 4077067..4078485 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
EGX44_RS19430 4078606..4080063 + 1458 WP_032466588.1 cell envelope integrity protein CreD -
EGX44_RS19435 4080148..4080666 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16467.40 Da        Isoelectric Point: 10.1176

>T114118 WP_012104676.1 NZ_CP033711:4075919-4076344 [Yersinia pseudotuberculosis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVLWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T114118 NZ_CP033711:4075919-4076344 [Yersinia pseudotuberculosis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCTATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT114118 WP_002209939.1 NZ_CP033711:4075672-4075938 [Yersinia pseudotuberculosis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT114118 NZ_CP033711:4075672-4075938 [Yersinia pseudotuberculosis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1R236

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References