Detailed information of TA system TA114107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 389902..390902
• Replicon: chromosome
• Accession: NZ_CP033711
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_582

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: EGX44_RS02420
• Protein ID: WP_011192520.1
• Coordinates: 389902..390360 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: EGX44_RS02425
• Protein ID: WP_002210982.1
• Coordinates: 390456..390902 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX44_RS02390	385716..386381	+	666	WP_002210975.1	phage shock protein PspA	-
EGX44_RS02395	386543..386770	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
EGX44_RS02400	386770..387129	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
EGX44_RS02405	387214..387456	+	243	WP_002216375.1	phage shock protein PspD	-
EGX44_RS02410	387437..388834	+	1398	WP_012105043.1	YcjX family protein	-
EGX44_RS02415	388831..389892	+	1062	WP_012413752.1	YcjF family protein	-
EGX44_RS02420	389902..390360	-	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
EGX44_RS02425	390456..390902	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
EGX44_RS02430	391239..392816	+	1578	WP_011192519.1	transcriptional regulator TyrR	-
EGX44_RS02435	392980..393483	-	504	WP_002210984.1	thiol peroxidase	-
EGX44_RS02440	393646..394626	+	981	WP_012413751.1	L-Ala-D/L-Glu epimerase	-
EGX44_RS02445	394668..395375	-	708	WP_038823925.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T114107 WP_011192520.1 NZ_CP033711:c390360-389902 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T114107 NZ_CP033711:c390360-389902 [Yersinia pseudotuberculosis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT114107 WP_002210982.1 NZ_CP033711:c390902-390456 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT114107 NZ_CP033711:c390902-390456 [Yersinia pseudotuberculosis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1