Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 204429..205049 Replicon chromosome
Accession NZ_CP033709
Organism Yersinia pseudotuberculosis strain FDAARGOS_583

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag EGX39_RS01455 Protein ID WP_002208622.1
Coordinates 204846..205049 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9PQI8
Locus tag EGX39_RS01450 Protein ID WP_025382853.1
Coordinates 204429..204797 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX39_RS01435 202634..202894 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
EGX39_RS01440 202910..203053 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
EGX39_RS01445 203917..204270 + 354 WP_002208619.1 hypothetical protein -
EGX39_RS01450 204429..204797 + 369 WP_025382853.1 Hha toxicity modulator TomB Antitoxin
EGX39_RS01455 204846..205049 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
EGX39_RS01465 205955..206344 + 390 WP_024063215.1 MGMT family protein -
EGX39_RS01470 206480..207001 - 522 WP_011191872.1 YbaY family lipoprotein -
EGX39_RS01475 207258..208118 + 861 WP_002208625.1 acyl-CoA thioesterase II -
EGX39_RS01480 208379..209668 - 1290 WP_002228344.1 ammonium transporter AmtB -
EGX39_RS01485 209708..210046 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T114093 WP_002208622.1 NZ_CP033709:204846-205049 [Yersinia pseudotuberculosis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T114093 NZ_CP033709:204846-205049 [Yersinia pseudotuberculosis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.98 Da        Isoelectric Point: 4.5221

>AT114093 WP_025382853.1 NZ_CP033709:204429-204797 [Yersinia pseudotuberculosis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSELSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT114093 NZ_CP033709:204429-204797 [Yersinia pseudotuberculosis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCGAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9PQI8

References