Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3909238..3910014 Replicon chromosome
Accession NZ_CP033707
Organism Yersinia pseudotuberculosis strain FDAARGOS_584

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H3B6R1
Locus tag EGX87_RS18435 Protein ID WP_012304462.1
Coordinates 3909238..3909621 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H3B780
Locus tag EGX87_RS18440 Protein ID WP_012304463.1
Coordinates 3909685..3910014 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX87_RS18410 3905282..3905737 - 456 WP_012304457.1 antitermination protein -
EGX87_RS22335 3905863..3906192 + 330 WP_050756398.1 hypothetical protein -
EGX87_RS18420 3906363..3907517 + 1155 WP_012304459.1 site-specific integrase -
EGX87_RS18425 3907723..3908571 - 849 WP_012304460.1 DUF4942 domain-containing protein -
EGX87_RS18430 3908746..3909241 - 496 Protein_3430 hypothetical protein -
EGX87_RS18435 3909238..3909621 - 384 WP_012304462.1 TA system toxin CbtA family protein Toxin
EGX87_RS18440 3909685..3910014 - 330 WP_012304463.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EGX87_RS18445 3910027..3910497 - 471 WP_012304464.1 DNA repair protein RadC -
EGX87_RS18450 3910568..3911389 - 822 WP_012304465.1 DUF945 domain-containing protein -
EGX87_RS18455 3911478..3911816 - 339 WP_012304466.1 hypothetical protein -
EGX87_RS18460 3911837..3912301 - 465 WP_012304467.1 hypothetical protein -
EGX87_RS18475 3912802..3913689 - 888 WP_012304468.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14442.40 Da        Isoelectric Point: 8.9291

>T114090 WP_012304462.1 NZ_CP033707:c3909621-3909238 [Yersinia pseudotuberculosis]
MQTLPVNPKRAAQTCPSPVEIWQKLLTHLLDQHYGLTLSDTSFSNETTIREHIDAGISLSYAVNFLVEKYELVRTDRTSF
TIVEQSPFITPIDILRARQATGLLKRSGYKAVSDITRGRARREEQSH

Download         Length: 384 bp

>T114090 NZ_CP033707:c3909621-3909238 [Yersinia pseudotuberculosis]
ATGCAAACCTTACCCGTAAACCCGAAACGGGCGGCACAAACCTGCCCGTCACCTGTTGAAATATGGCAAAAACTGCTAAC
GCATCTGCTCGATCAACACTATGGACTCACACTTAGTGATACCTCGTTCAGCAATGAAACCACCATCCGTGAACATATTG
ACGCCGGAATATCCCTCAGCTATGCGGTGAACTTCCTGGTGGAAAAATATGAACTGGTACGCACTGACCGGACCAGTTTC
ACCATTGTGGAGCAATCACCGTTTATCACCCCAATCGATATTCTCCGCGCCAGGCAAGCCACCGGTCTCCTGAAGCGCAG
TGGTTATAAAGCCGTCAGTGACATTACCCGTGGCAGAGCTCGGCGAGAGGAGCAAAGCCATTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12234.84 Da        Isoelectric Point: 6.4825

>AT114090 WP_012304463.1 NZ_CP033707:c3910014-3909685 [Yersinia pseudotuberculosis]
MSLTLSHEWGLKSDITPRFGARLVQEGNRLHFRADHAGFNGAFSEDEALRLDQAFPLMLKQLELKLLSGELNPRRQHCVT
LNHNGLTCEADTLGSHGYVYITIYPASPE

Download         Length: 330 bp

>AT114090 NZ_CP033707:c3910014-3909685 [Yersinia pseudotuberculosis]
ATGTCATTAACACTATCCCATGAATGGGGGCTAAAAAGCGATATCACCCCACGCTTTGGCGCAAGATTGGTGCAGGAAGG
CAATCGCCTGCACTTTCGGGCTGACCATGCGGGTTTTAACGGTGCATTCAGTGAGGATGAGGCGCTGCGGCTTGACCAAG
CGTTTCCACTGATGCTCAAACAGCTTGAACTTAAGCTGCTATCCGGTGAGCTCAATCCTCGTCGTCAGCATTGCGTTACG
TTGAACCACAATGGCCTGACCTGCGAAGCTGACACCCTCGGCTCTCACGGGTATGTCTATATCACTATTTACCCGGCAAG
CCCGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3B6R1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3B780

References