Detailed information of TA system TA114081

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2590009..2590975
• Replicon: chromosome
• Accession: NZ_CP033707
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_584

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: EGX87_RS12205
• Protein ID: WP_011192520.1
• Coordinates: 2590009..2590467 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: EGX87_RS12210
• Protein ID: WP_002210982.1
• Coordinates: 2590529..2590975 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX87_RS12175	2585823..2586488	+	666	WP_011192521.1	phage shock protein PspA	-
EGX87_RS12180	2586650..2586877	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
EGX87_RS12185	2586877..2587236	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
EGX87_RS12190	2587321..2587563	+	243	WP_002216375.1	phage shock protein PspD	-
EGX87_RS12195	2587544..2588941	+	1398	WP_012105043.1	YcjX family protein	-
EGX87_RS12200	2588938..2589999	+	1062	WP_002210980.1	YcjF family protein	-
EGX87_RS12205	2590009..2590467	-	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
EGX87_RS12210	2590529..2590975	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
EGX87_RS12215	2591312..2592889	+	1578	WP_011192519.1	transcriptional regulator TyrR	-
EGX87_RS12220	2593070..2593573	-	504	WP_002210984.1	thiol peroxidase	-
EGX87_RS12225	2593736..2594710	+	975	WP_012105045.1	L-Ala-D/L-Glu epimerase	-
EGX87_RS12230	2594752..2595459	-	708	WP_032466942.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T114081 WP_011192520.1 NZ_CP033707:c2590467-2590009 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T114081 NZ_CP033707:c2590467-2590009 [Yersinia pseudotuberculosis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT114081 WP_002210982.1 NZ_CP033707:c2590975-2590529 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT114081 NZ_CP033707:c2590975-2590529 [Yersinia pseudotuberculosis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGATTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1