114072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2863632..2864287 Replicon chromosome
Accession NZ_CP033702
Organism Burkholderia pseudomallei strain FDAARGOS_594

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag EGY14_RS31145 Protein ID WP_006027262.1
Coordinates 2863632..2863928 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag EGY14_RS31150 Protein ID WP_004202809.1
Coordinates 2863931..2864287 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY14_RS31110 2859084..2859686 - 603 WP_076982283.1 site-specific DNA-methyltransferase -
EGY14_RS31115 2859584..2859997 - 414 WP_004527843.1 phage tail protein I -
EGY14_RS31120 2859990..2860316 - 327 WP_004552669.1 hypothetical protein -
EGY14_RS31135 2861088..2861705 - 618 WP_031313497.1 DUF4276 family protein -
EGY14_RS31140 2861708..2862964 - 1257 WP_004552667.1 AAA family ATPase -
EGY14_RS31145 2863632..2863928 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGY14_RS31150 2863931..2864287 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
EGY14_RS31155 2864331..2865386 - 1056 WP_004199886.1 phage portal protein -
EGY14_RS31160 2865383..2865880 - 498 WP_004199888.1 terminase -
EGY14_RS31165 2866333..2866653 + 321 WP_123875386.1 hypothetical protein -
EGY14_RS31170 2866869..2867492 - 624 WP_123875387.1 hypothetical protein -
EGY14_RS31175 2867502..2868542 - 1041 WP_055312704.1 DUF262 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2860926..2883178 22252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T114072 WP_006027262.1 NZ_CP033702:2863632-2863928 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T114072 NZ_CP033702:2863632-2863928 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT114072 WP_004202809.1 NZ_CP033702:2863931-2864287 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT114072 NZ_CP033702:2863931-2864287 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References