Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3413802..3414422 Replicon chromosome
Accession NZ_CP033699
Organism Yersinia pestis strain FDAARGOS_601

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag EGX46_RS16935 Protein ID WP_002208622.1
Coordinates 3414219..3414422 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag EGX46_RS16930 Protein ID WP_002218472.1
Coordinates 3413802..3414170 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX46_RS16915 3411997..3412257 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
EGX46_RS16920 3412273..3412416 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
EGX46_RS16925 3413290..3413643 + 354 WP_002208619.1 hypothetical protein -
EGX46_RS16930 3413802..3414170 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
EGX46_RS16935 3414219..3414422 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
EGX46_RS16945 3415310..3415699 + 390 WP_002208623.1 MGMT family protein -
EGX46_RS16950 3415835..3416356 - 522 WP_002208624.1 lipoprotein -
EGX46_RS16955 3416613..3417473 + 861 WP_002208625.1 acyl-CoA thioesterase II -
EGX46_RS16960 3417733..3419022 - 1290 WP_011566312.1 ammonium transporter AmtB -
EGX46_RS16965 3419062..3419400 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T114068 WP_002208622.1 NZ_CP033699:3414219-3414422 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T114068 NZ_CP033699:3414219-3414422 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT114068 WP_002218472.1 NZ_CP033699:3413802-3414170 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT114068 NZ_CP033699:3413802-3414170 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References