Detailed information of TA system TA114067

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2388306..2389272
• Replicon: chromosome
• Accession: NZ_CP033699
• Organism: Yersinia pestis strain FDAARGOS_601

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: EGX46_RS11945
• Protein ID: WP_002210981.1
• Coordinates: 2388814..2389272 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E1NXA5
• Locus tag: EGX46_RS11940
• Protein ID: WP_002220311.1
• Coordinates: 2388306..2388752 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX46_RS11920	2383896..2384870	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
EGX46_RS11925	2385033..2385536	+	504	WP_002210984.1	thiol peroxidase	-
EGX46_RS11930	2385789..2386247	+	459	WP_002213775.1	IS200/IS605-like element IS1541B family transposase	-
EGX46_RS11935	2386394..2387971	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
EGX46_RS11940	2388306..2388752	+	447	WP_002220311.1	DUF2384 domain-containing protein	Antitoxin
EGX46_RS11945	2388814..2389272	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
EGX46_RS11950	2389282..2390343	-	1062	WP_002210980.1	YcjF family protein	-
EGX46_RS11955	2390340..2391737	-	1398	WP_002210979.1	YcjX family protein	-
EGX46_RS11960	2391718..2391960	-	243	WP_002216375.1	phage shock protein PspD	-
EGX46_RS11965	2392045..2392404	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
EGX46_RS11970	2392404..2392631	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
EGX46_RS11975	2392793..2393458	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2386002..2386247	245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T114067 WP_002210981.1 NZ_CP033699:2388814-2389272 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T114067 NZ_CP033699:2388814-2389272 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16332.83 Da
• Isoelectric Point: 9.0335

>AT114067 WP_002220311.1 NZ_CP033699:2388306-2388752 [Yersinia pestis]
MRAYRPNPATKMGTLWSEIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT114067 NZ_CP033699:2388306-2388752 [Yersinia pestis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGAGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E1NXA5