Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1830694..1831340 Replicon chromosome
Accession NZ_CP033699
Organism Yersinia pestis strain FDAARGOS_601

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag EGX46_RS09260 Protein ID WP_002214976.1
Coordinates 1831158..1831340 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag EGX46_RS09255 Protein ID WP_002211129.1
Coordinates 1830694..1831113 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX46_RS09235 1825765..1826760 + 996 WP_002211125.1 substrate-binding domain-containing protein -
EGX46_RS09240 1826826..1828403 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
EGX46_RS09245 1828406..1829428 + 1023 WP_002214974.1 ABC transporter permease -
EGX46_RS09250 1829477..1830436 + 960 WP_002211128.1 sugar kinase -
EGX46_RS09255 1830694..1831113 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EGX46_RS09260 1831158..1831340 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
EGX46_RS09265 1831547..1832329 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
EGX46_RS09270 1832332..1832601 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
EGX46_RS09275 1832707..1833447 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
EGX46_RS09280 1833528..1834064 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
EGX46_RS09285 1834064..1834480 - 417 WP_002211134.1 flagellar motor switch protein FliN -
EGX46_RS09290 1834477..1835478 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
EGX46_RS09295 1835484..1835954 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T114066 WP_002214976.1 NZ_CP033699:c1831340-1831158 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T114066 NZ_CP033699:c1831340-1831158 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT114066 WP_002211129.1 NZ_CP033699:c1831113-1830694 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT114066 NZ_CP033699:c1831113-1830694 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References