Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4418959..4419579 Replicon chromosome
Accession NZ_CP033696
Organism Yersinia pestis strain FDAARGOS_602

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag EGX42_RS21920 Protein ID WP_002208622.1
Coordinates 4419376..4419579 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag EGX42_RS21915 Protein ID WP_002218472.1
Coordinates 4418959..4419327 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX42_RS21900 4417154..4417414 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
EGX42_RS21905 4417430..4417573 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
EGX42_RS21910 4418447..4418800 + 354 WP_002208619.1 hypothetical protein -
EGX42_RS21915 4418959..4419327 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
EGX42_RS21920 4419376..4419579 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
EGX42_RS21930 4420467..4420856 + 390 WP_002208623.1 MGMT family protein -
EGX42_RS21935 4420992..4421513 - 522 WP_002208624.1 lipoprotein -
EGX42_RS21940 4421770..4422630 + 861 WP_002208625.1 acyl-CoA thioesterase II -
EGX42_RS21945 4422890..4424179 - 1290 WP_002228344.1 ammonium transporter AmtB -
EGX42_RS21950 4424267..4424557 - 291 WP_042659203.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T114052 WP_002208622.1 NZ_CP033696:4419376-4419579 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T114052 NZ_CP033696:4419376-4419579 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT114052 WP_002218472.1 NZ_CP033696:4418959-4419327 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT114052 NZ_CP033696:4418959-4419327 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References