Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 4270328..4270974 Replicon chromosome
Accession NZ_CP033696
Organism Yersinia pestis strain FDAARGOS_602

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag EGX42_RS21165 Protein ID WP_002214976.1
Coordinates 4270328..4270510 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag EGX42_RS21170 Protein ID WP_002211129.1
Coordinates 4270555..4270974 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX42_RS21130 4265714..4266184 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
EGX42_RS21135 4266190..4267191 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
EGX42_RS21140 4267188..4267604 + 417 WP_002211134.1 flagellar motor switch protein FliN -
EGX42_RS21145 4267604..4268140 + 537 WP_002231108.1 flagellar biosynthetic protein FliO -
EGX42_RS21150 4268221..4268961 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
EGX42_RS21155 4269067..4269336 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
EGX42_RS21160 4269339..4270121 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
EGX42_RS21165 4270328..4270510 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
EGX42_RS21170 4270555..4270974 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EGX42_RS21175 4271232..4272191 - 960 WP_002211128.1 sugar kinase -
EGX42_RS21180 4272240..4273262 - 1023 WP_002214974.1 ABC transporter permease -
EGX42_RS21185 4273265..4274842 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
EGX42_RS21190 4274908..4275903 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T114043 WP_002214976.1 NZ_CP033696:4270328-4270510 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T114043 NZ_CP033696:4270328-4270510 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT114043 WP_002211129.1 NZ_CP033696:4270555-4270974 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT114043 NZ_CP033696:4270555-4270974 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References