Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2419655..2420327 Replicon chromosome
Accession NZ_CP033696
Organism Yersinia pestis strain FDAARGOS_602

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag EGX42_RS12480 Protein ID WP_002215144.1
Coordinates 2419655..2420080 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag EGX42_RS12485 Protein ID WP_002209939.1
Coordinates 2420061..2420327 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX42_RS12460 2415322..2415840 + 519 WP_002209934.1 flavodoxin FldB -
EGX42_RS12465 2415930..2417387 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
EGX42_RS12470 2417508..2418932 - 1425 WP_002230639.1 two-component system sensor histidine kinase CreC -
EGX42_RS12475 2418957..2419655 - 699 WP_002209937.1 two-component system response regulator CreB -
EGX42_RS12480 2419655..2420080 - 426 WP_002215144.1 protein YgfX Toxin
EGX42_RS12485 2420061..2420327 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
EGX42_RS12490 2420644..2421636 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
EGX42_RS12495 2421709..2422206 - 498 WP_002209941.1 DUF2165 family protein -
EGX42_RS12500 2422464..2423165 - 702 WP_002209942.1 hemolysin III family protein -
EGX42_RS12505 2423367..2424470 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T114042 WP_002215144.1 NZ_CP033696:c2420080-2419655 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T114042 NZ_CP033696:c2420080-2419655 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT114042 WP_002209939.1 NZ_CP033696:c2420327-2420061 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT114042 NZ_CP033696:c2420327-2420061 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References