Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4529158..4529778 Replicon chromosome
Accession NZ_CP033690
Organism Yersinia pestis strain FDAARGOS_603

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag EGX74_RS21825 Protein ID WP_002208622.1
Coordinates 4529575..4529778 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag EGX74_RS21820 Protein ID WP_002218472.1
Coordinates 4529158..4529526 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX74_RS21805 4527353..4527613 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
EGX74_RS21810 4527629..4527772 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
EGX74_RS21815 4528646..4528999 + 354 WP_002208619.1 hypothetical protein -
EGX74_RS21820 4529158..4529526 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
EGX74_RS21825 4529575..4529778 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
EGX74_RS21835 4530666..4531055 + 390 WP_002208623.1 MGMT family protein -
EGX74_RS21840 4531191..4531712 - 522 WP_002208624.1 lipoprotein -
EGX74_RS21845 4531969..4532829 + 861 WP_002208625.1 acyl-CoA thioesterase II -
EGX74_RS21850 4533089..4534378 - 1290 WP_002228344.1 ammonium transporter AmtB -
EGX74_RS21855 4534418..4534756 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T114038 WP_002208622.1 NZ_CP033690:4529575-4529778 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T114038 NZ_CP033690:4529575-4529778 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT114038 WP_002218472.1 NZ_CP033690:4529158-4529526 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT114038 NZ_CP033690:4529158-4529526 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References