Detailed information of TA system TA114037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 3517933..3518899
• Replicon: chromosome
• Accession: NZ_CP033690
• Organism: Yersinia pestis strain FDAARGOS_603

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: EGX74_RS16960
• Protein ID: WP_002210981.1
• Coordinates: 3518441..3518899 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: EGX74_RS16955
• Protein ID: WP_002210982.1
• Coordinates: 3517933..3518379 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX74_RS16935	3513522..3514496	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
EGX74_RS16940	3514659..3515162	+	504	WP_002210984.1	thiol peroxidase	-
EGX74_RS16945	3515415..3515873	+	459	WP_002213775.1	IS200/IS605-like element IS1541B family transposase	-
EGX74_RS16950	3516020..3517597	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
EGX74_RS16955	3517933..3518379	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
EGX74_RS16960	3518441..3518899	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
EGX74_RS16965	3518909..3519970	-	1062	WP_002210980.1	YcjF family protein	-
EGX74_RS16970	3519967..3521364	-	1398	WP_002210979.1	YcjX family protein	-
EGX74_RS16975	3521345..3521587	-	243	WP_002216375.1	phage shock protein PspD	-
EGX74_RS16980	3521672..3522031	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
EGX74_RS16985	3522031..3522258	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
EGX74_RS16990	3522420..3523085	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3515415..3515873	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T114037 WP_002210981.1 NZ_CP033690:3518441-3518899 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T114037 NZ_CP033690:3518441-3518899 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT114037 WP_002210982.1 NZ_CP033690:3517933-3518379 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT114037 NZ_CP033690:3517933-3518379 [Yersinia pestis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1