Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2955810..2956456 Replicon chromosome
Accession NZ_CP033690
Organism Yersinia pestis strain FDAARGOS_603

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag EGX74_RS14265 Protein ID WP_002214976.1
Coordinates 2956274..2956456 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag EGX74_RS14260 Protein ID WP_002211129.1
Coordinates 2955810..2956229 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX74_RS14240 2950881..2951876 + 996 WP_002211125.1 substrate-binding domain-containing protein -
EGX74_RS14245 2951942..2953519 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
EGX74_RS14250 2953522..2954544 + 1023 WP_002214974.1 ABC transporter permease -
EGX74_RS14255 2954593..2955552 + 960 WP_002223882.1 sugar kinase -
EGX74_RS14260 2955810..2956229 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EGX74_RS14265 2956274..2956456 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
EGX74_RS14270 2956663..2957445 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
EGX74_RS14275 2957448..2957717 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
EGX74_RS14280 2957823..2958563 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
EGX74_RS14285 2958644..2959180 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
EGX74_RS14290 2959180..2959596 - 417 WP_002211134.1 flagellar motor switch protein FliN -
EGX74_RS14295 2959593..2960594 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
EGX74_RS14300 2960600..2961070 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T114036 WP_002214976.1 NZ_CP033690:c2956456-2956274 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T114036 NZ_CP033690:c2956456-2956274 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT114036 WP_002211129.1 NZ_CP033690:c2956229-2955810 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT114036 NZ_CP033690:c2956229-2955810 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References