Detailed information of TA system TA113994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5648898..5649502
• Replicon: chromosome
• Accession: NZ_CP033672
• Organism: Burkholderia glumae strain BGR80S

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EFP20_RS25535
• Protein ID: WP_017922254.1
• Coordinates: 5648898..5649080 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EFP20_RS25540
• Protein ID: WP_017922253.1
• Coordinates: 5649107..5649502 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFP20_RS25510 (EFP20_25290)	5644702..5644950	-	249	WP_039201402.1	gpW family head-tail joining protein	-
EFP20_RS25515 (EFP20_25295)	5644967..5647039	-	2073	WP_257755350.1	phage terminase large subunit family protein	-
EFP20_RS25520 (EFP20_25300)	5647092..5647796	-	705	WP_251107513.1	hypothetical protein	-
EFP20_RS25525 (EFP20_25305)	5647846..5648121	-	276	WP_257834622.1	DUF2591 domain-containing protein	-
EFP20_RS25530 (EFP20_25310)	5648127..5648825	-	699	WP_257834624.1	hypothetical protein	-
EFP20_RS25535 (EFP20_25315)	5648898..5649080	+	183	WP_017922254.1	type II toxin-antitoxin system HicA family toxin	Toxin
EFP20_RS25540 (EFP20_25320)	5649107..5649502	+	396	WP_017922253.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EFP20_RS25545 (EFP20_25325)	5649799..5650230	-	432	WP_157384052.1	hypothetical protein	-
EFP20_RS25550 (EFP20_25330)	5650223..5650786	-	564	WP_257834627.1	hypothetical protein	-
EFP20_RS25555	5650954..5651274	-	321	WP_124837795.1	hypothetical protein	-
EFP20_RS25560 (EFP20_25335)	5651302..5653101	-	1800	WP_124837793.1	toprim domain-containing protein	-
EFP20_RS25565 (EFP20_25340)	5653098..5653550	-	453	WP_051415274.1	HNH endonuclease signature motif containing protein	-
EFP20_RS25570 (EFP20_25345)	5653547..5654428	-	882	WP_257756926.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	5566591..5669975	103384

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-123)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6599.76 Da
• Isoelectric Point: 11.2641

>T113994 WP_017922254.1 NZ_CP033672:5648898-5649080 [Burkholderia glumae]
MNSANLIRTLKADGWYLVNTVGSHHQFKHATKPGKVTVPHPKKDLPLGTVRSILKQAGLK

Nucleotide

• Length: 183 bp

>T113994 NZ_CP033672:5648898-5649080 [Burkholderia glumae]
ATGAACAGCGCGAACCTTATCCGAACCCTGAAAGCCGACGGCTGGTATCTCGTCAATACCGTCGGCTCGCATCACCAGTT
CAAGCATGCGACCAAGCCCGGTAAGGTGACGGTGCCTCACCCGAAGAAAGACCTTCCCCTAGGCACCGTGCGCAGCATCC
TGAAACAAGCCGGTCTGAAATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14466.21 Da
• Isoelectric Point: 4.5532

>AT113994 WP_017922253.1 NZ_CP033672:5649107-5649502 [Burkholderia glumae]
MLYPLYVHVGDDKHAHGVTFPDFPGCHAAADSWDELPAAVQEAAQAHFEGDDSPIPEPSALEDLTRDPEYTGGVWMIFDI
DLSKINTKAVRFNVSMSERLLQKIDAKARARKLSRSAFLAIAAEHEMEADA

Nucleotide

• Length: 396 bp

>AT113994 NZ_CP033672:5649107-5649502 [Burkholderia glumae]
ATGCTCTATCCGCTCTATGTCCACGTCGGCGACGACAAGCACGCACATGGCGTCACTTTTCCCGACTTCCCCGGCTGCCA
CGCTGCGGCCGACTCCTGGGACGAACTGCCCGCAGCCGTGCAGGAGGCCGCCCAGGCCCATTTCGAGGGCGACGACAGCC
CGATTCCCGAGCCTTCCGCGCTCGAAGATTTGACGCGCGATCCGGAATACACCGGCGGCGTCTGGATGATCTTCGATATC
GACCTGTCGAAGATCAACACGAAAGCCGTGCGCTTCAACGTCAGCATGTCCGAGCGGCTGCTCCAGAAGATCGACGCCAA
GGCGCGCGCGCGCAAACTCTCGCGATCGGCCTTCCTTGCGATTGCGGCAGAACACGAAATGGAAGCTGACGCCTAA