Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1971128..1971903 Replicon chromosome
Accession NZ_CP033672
Organism Burkholderia glumae strain BGR80S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag EFP20_RS09080 Protein ID WP_015877380.1
Coordinates 1971128..1971625 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag EFP20_RS09085 Protein ID WP_015877381.1
Coordinates 1971622..1971903 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFP20_RS09045 (EFP20_09055) 1967149..1967244 - 96 Protein_1654 IS5/IS1182 family transposase -
EFP20_RS09050 (EFP20_09060) 1967316..1967861 - 546 Protein_1655 IS3 family transposase -
EFP20_RS09055 (EFP20_09065) 1968054..1968859 + 806 WP_085962370.1 IS5 family transposase -
EFP20_RS09060 1968825..1969136 - 312 WP_015877377.1 hypothetical protein -
EFP20_RS09065 1969153..1969404 - 252 WP_230674552.1 hypothetical protein -
EFP20_RS09070 (EFP20_09070) 1969534..1970136 - 603 Protein_1659 RHS domain-containing protein -
EFP20_RS09075 (EFP20_09075) 1970550..1971047 - 498 WP_015877379.1 ProQ/FINO family protein -
EFP20_RS09080 (EFP20_09080) 1971128..1971625 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
EFP20_RS09085 (EFP20_09085) 1971622..1971903 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
EFP20_RS09090 (EFP20_09090) 1971900..1972277 - 378 WP_173941242.1 hypothetical protein -
EFP20_RS09095 (EFP20_09095) 1972360..1972722 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1967292..1967834 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T113993 WP_015877380.1 NZ_CP033672:c1971625-1971128 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T113993 NZ_CP033672:c1971625-1971128 [Burkholderia glumae]
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT113993 WP_015877381.1 NZ_CP033672:c1971903-1971622 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT113993 NZ_CP033672:c1971903-1971622 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References