Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapC-vagC/VapC-VagC |
| Location | 95291..95928 | Replicon | plasmid p3_BGR21S |
| Accession | NZ_CP033670 | ||
| Organism | Burkholderia glumae strain BGR21S | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | C5AP38 |
| Locus tag | EFP19_RS31710 | Protein ID | WP_012735347.1 |
| Coordinates | 95291..95692 (-) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | - |
| Locus tag | EFP19_RS31715 | Protein ID | WP_017924531.1 |
| Coordinates | 95692..95928 (-) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EFP19_RS31665 (EFP19_31515) | 91324..91611 | + | 288 | WP_258898319.1 | hypothetical protein | - |
| EFP19_RS31670 (EFP19_31520) | 91712..91954 | - | 243 | WP_012735345.1 | hypothetical protein | - |
| EFP19_RS31675 | 91972..92301 | - | 330 | WP_155297075.1 | hypothetical protein | - |
| EFP19_RS31680 (EFP19_31525) | 92548..92916 | - | 369 | WP_153479214.1 | hypothetical protein | - |
| EFP19_RS31685 (EFP19_31530) | 92932..93615 | - | 684 | WP_252836578.1 | DUF4145 domain-containing protein | - |
| EFP19_RS31690 (EFP19_31535) | 93628..94035 | - | 408 | WP_258898320.1 | hypothetical protein | - |
| EFP19_RS31695 (EFP19_31540) | 94010..94255 | - | 246 | WP_258898321.1 | hypothetical protein | - |
| EFP19_RS31700 (EFP19_31545) | 94677..94904 | - | 228 | WP_258898322.1 | hypothetical protein | - |
| EFP19_RS31705 (EFP19_31550) | 94916..95266 | - | 351 | WP_258898323.1 | hypothetical protein | - |
| EFP19_RS31710 (EFP19_31555) | 95291..95692 | - | 402 | WP_012735347.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| EFP19_RS31715 (EFP19_31560) | 95692..95928 | - | 237 | WP_017924531.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| EFP19_RS31720 (EFP19_31570) | 96265..96954 | - | 690 | WP_258898324.1 | hypothetical protein | - |
| EFP19_RS31725 (EFP19_31575) | 97041..98867 | - | 1827 | WP_258898325.1 | site-specific integrase | - |
| EFP19_RS31730 (EFP19_31580) | 98864..99244 | - | 381 | WP_258898326.1 | hypothetical protein | - |
| EFP19_RS31735 (EFP19_31585) | 99279..99596 | - | 318 | WP_258898327.1 | hypothetical protein | - |
| EFP19_RS31740 (EFP19_31590) | 99659..100069 | - | 411 | WP_258898328.1 | type II toxin-antitoxin system VapC family toxin | - |
| EFP19_RS31745 (EFP19_31595) | 100060..100314 | - | 255 | WP_257744773.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| EFP19_RS31750 (EFP19_31600) | 100495..100695 | - | 201 | WP_012735350.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..100711 | 100711 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14847.12 Da Isoelectric Point: 5.2138
>T113991 WP_012735347.1 NZ_CP033670:c95692-95291 [Burkholderia glumae]
MPRFMLDTNMCIYLMKNQPEQVAKRFAECFVGDVVMSAITYAELEYGVAVSDNRAKERRNLAALIEDILVAPFDAAAAVA
YGPIREATRERKKDHLDKLIAAHAVALDVVLVTNNAKDFASYPGIKLDNWLND
MPRFMLDTNMCIYLMKNQPEQVAKRFAECFVGDVVMSAITYAELEYGVAVSDNRAKERRNLAALIEDILVAPFDAAAAVA
YGPIREATRERKKDHLDKLIAAHAVALDVVLVTNNAKDFASYPGIKLDNWLND
Download Length: 402 bp
>T113991 NZ_CP033670:c95692-95291 [Burkholderia glumae]
ATGCCGCGCTTCATGCTCGACACCAATATGTGCATCTACCTGATGAAGAACCAGCCTGAGCAGGTAGCAAAGCGTTTCGC
GGAGTGCTTCGTCGGTGACGTGGTGATGTCCGCTATCACATATGCCGAGCTTGAATACGGTGTCGCGGTTTCTGACAACC
GGGCGAAAGAGCGGCGGAACCTCGCCGCGTTGATTGAGGACATTCTGGTTGCTCCGTTTGATGCTGCTGCGGCTGTAGCC
TATGGTCCGATTCGCGAGGCTACACGGGAGCGCAAGAAGGACCACCTAGACAAGTTGATCGCCGCCCATGCAGTTGCGCT
TGACGTGGTGCTTGTCACAAACAACGCGAAGGACTTCGCAAGCTATCCGGGTATCAAGCTCGACAACTGGCTGAATGACT
GA
ATGCCGCGCTTCATGCTCGACACCAATATGTGCATCTACCTGATGAAGAACCAGCCTGAGCAGGTAGCAAAGCGTTTCGC
GGAGTGCTTCGTCGGTGACGTGGTGATGTCCGCTATCACATATGCCGAGCTTGAATACGGTGTCGCGGTTTCTGACAACC
GGGCGAAAGAGCGGCGGAACCTCGCCGCGTTGATTGAGGACATTCTGGTTGCTCCGTTTGATGCTGCTGCGGCTGTAGCC
TATGGTCCGATTCGCGAGGCTACACGGGAGCGCAAGAAGGACCACCTAGACAAGTTGATCGCCGCCCATGCAGTTGCGCT
TGACGTGGTGCTTGTCACAAACAACGCGAAGGACTTCGCAAGCTATCCGGGTATCAAGCTCGACAACTGGCTGAATGACT
GA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8965.10 Da Isoelectric Point: 6.3676
>AT113991 WP_017924531.1 NZ_CP033670:c95928-95692 [Burkholderia glumae]
MQTTRVFRNGNSQAVRIPADLAYERSDVELEIERVGDEIRIRPARRPLTGVLKKFAKFSQDFMAEGRGEQEQAEREGL
MQTTRVFRNGNSQAVRIPADLAYERSDVELEIERVGDEIRIRPARRPLTGVLKKFAKFSQDFMAEGRGEQEQAEREGL
Download Length: 237 bp
>AT113991 NZ_CP033670:c95928-95692 [Burkholderia glumae]
ATGCAGACAACCCGAGTTTTCAGGAACGGCAACTCTCAGGCCGTTCGCATCCCCGCCGATCTTGCCTATGAGCGCAGCGA
CGTTGAGCTTGAAATCGAGCGCGTGGGCGACGAAATCCGCATCCGACCGGCTCGACGTCCCTTGACGGGGGTACTCAAGA
AATTTGCCAAATTCAGCCAAGATTTCATGGCCGAGGGGCGCGGCGAGCAGGAACAAGCTGAACGTGAGGGTCTGTAA
ATGCAGACAACCCGAGTTTTCAGGAACGGCAACTCTCAGGCCGTTCGCATCCCCGCCGATCTTGCCTATGAGCGCAGCGA
CGTTGAGCTTGAAATCGAGCGCGTGGGCGACGAAATCCGCATCCGACCGGCTCGACGTCCCTTGACGGGGGTACTCAAGA
AATTTGCCAAATTCAGCCAAGATTTCATGGCCGAGGGGCGCGGCGAGCAGGAACAAGCTGAACGTGAGGGTCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|