Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2032877..2033552 Replicon chromosome
Accession NZ_CP033665
Organism Burkholderia glumae strain BGR15S

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EFP17_RS28410 Protein ID WP_251119048.1
Coordinates 2032877..2033062 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EFP17_RS28415 Protein ID WP_257806308.1
Coordinates 2033133..2033552 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFP17_RS28360 2028068..2028295 - 228 WP_257806294.1 hypothetical protein -
EFP17_RS28365 (EFP17_28160) 2028603..2029058 - 456 WP_251119056.1 hypothetical protein -
EFP17_RS28370 (EFP17_28165) 2029055..2029624 - 570 WP_257806295.1 hypothetical protein -
EFP17_RS28375 (EFP17_28170) 2029627..2030289 - 663 WP_257806296.1 KilA-N domain-containing protein -
EFP17_RS28380 (EFP17_28175) 2030289..2030510 - 222 WP_257806297.1 hypothetical protein -
EFP17_RS28385 (EFP17_28180) 2030503..2030781 - 279 WP_257806298.1 hypothetical protein -
EFP17_RS28390 (EFP17_28185) 2030774..2031091 - 318 WP_257806299.1 hypothetical protein -
EFP17_RS28395 (EFP17_28190) 2031173..2031358 - 186 WP_257806301.1 hypothetical protein -
EFP17_RS28400 2031355..2032125 - 771 WP_257806303.1 KilA-N domain-containing protein -
EFP17_RS28405 (EFP17_28200) 2032243..2032701 + 459 WP_257806304.1 Arc family DNA-binding protein -
EFP17_RS28410 (EFP17_28205) 2032877..2033062 + 186 WP_251119048.1 type II toxin-antitoxin system HicA family toxin Toxin
EFP17_RS28415 (EFP17_28210) 2033133..2033552 + 420 WP_257806308.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EFP17_RS28420 (EFP17_28215) 2033693..2034469 + 777 WP_257806311.1 SGNH/GDSL hydrolase family protein -
EFP17_RS28425 (EFP17_28220) 2034472..2035548 + 1077 WP_257806313.1 acyltransferase -
EFP17_RS28430 2035550..2037682 - 2133 WP_257806316.1 hypothetical protein -
EFP17_RS28435 (EFP17_28225) 2037679..2038008 - 330 WP_257806319.1 hypothetical protein -
EFP17_RS28440 2038018..2038236 - 219 WP_251119041.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2014715..2084634 69919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6934.04 Da        Isoelectric Point: 10.7447

>T113989 WP_251119048.1 NZ_CP033665:2032877-2033062 [Burkholderia glumae]
MKYSEFRKWLKKQGAEFEKHKSGSSHFRVTLNGKTTIFPDHGSKEIGTGLVEAIKKQLGIK

Download         Length: 186 bp

>T113989 NZ_CP033665:2032877-2033062 [Burkholderia glumae]
ATGAAGTACAGCGAGTTCCGCAAGTGGCTGAAGAAACAGGGTGCTGAGTTCGAAAAGCACAAATCTGGTTCAAGCCACTT
CCGGGTTACTTTGAACGGCAAGACCACCATCTTCCCGGACCACGGCAGCAAGGAAATCGGTACCGGGTTGGTCGAGGCGA
TCAAGAAGCAACTCGGAATCAAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15070.56 Da        Isoelectric Point: 5.2435

>AT113989 WP_257806308.1 NZ_CP033665:2033133-2033552 [Burkholderia glumae]
MLSYPVTLTPDSNGTLLVTFPDVPEAISVGENVEDALAQGLDALEAAFEIYFNEKRLIPAPSQAEPGQHVVTLPVLVASK
VLLANEAIEQKVRKAELARRLKVAPVQVDRLFKFSHGSKIEMIEAALGVLGKRLEIKAV

Download         Length: 420 bp

>AT113989 NZ_CP033665:2033133-2033552 [Burkholderia glumae]
ATGCTGTCGTATCCCGTCACCCTGACGCCGGACTCGAACGGTACTTTGCTGGTCACGTTCCCGGACGTTCCGGAAGCCAT
CTCTGTTGGAGAGAACGTTGAGGACGCGCTCGCTCAAGGGCTTGATGCGCTCGAAGCAGCCTTTGAGATCTACTTCAACG
AGAAGCGGCTTATCCCCGCTCCATCACAAGCAGAGCCTGGGCAACACGTCGTTACCCTGCCCGTTCTCGTGGCATCAAAG
GTCTTGCTGGCAAACGAAGCCATCGAACAGAAAGTTCGAAAGGCCGAGCTTGCACGCCGGCTCAAGGTCGCCCCGGTGCA
GGTCGATCGTCTATTCAAGTTCAGCCACGGCTCCAAGATCGAGATGATCGAGGCTGCCCTTGGCGTGCTTGGAAAGCGCC
TAGAGATCAAGGCTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References