Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1709442..1710217 Replicon chromosome
Accession NZ_CP033665
Organism Burkholderia glumae strain BGR15S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag EFP17_RS26950 Protein ID WP_015877380.1
Coordinates 1709442..1709939 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag EFP17_RS26955 Protein ID WP_015877381.1
Coordinates 1709936..1710217 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFP17_RS26915 1704494..1704805 - 312 WP_015877377.1 hypothetical protein -
EFP17_RS26920 1704822..1705073 - 252 WP_230674552.1 hypothetical protein -
EFP17_RS26925 (EFP17_26755) 1705203..1705805 - 603 Protein_1349 RHS domain-containing protein -
EFP17_RS26930 (EFP17_26760) 1706219..1706392 - 174 WP_257806536.1 ProQ/FinO family protein -
EFP17_RS26935 (EFP17_26765) 1706508..1708094 - 1587 WP_012732733.1 IS66 family transposase -
EFP17_RS26940 (EFP17_26770) 1708194..1708547 - 354 WP_012732734.1 IS66 family insertion sequence element accessory protein TnpB -
EFP17_RS26945 (EFP17_26775) 1708547..1709002 - 456 WP_012732735.1 transposase -
EFP17_RS26950 (EFP17_26785) 1709442..1709939 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
EFP17_RS26955 (EFP17_26790) 1709936..1710217 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
EFP17_RS26960 (EFP17_26795) 1710214..1710591 - 378 WP_173941242.1 hypothetical protein -
EFP17_RS26965 1710674..1711036 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1690306..1738464 48158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T113988 WP_015877380.1 NZ_CP033665:c1709939-1709442 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T113988 NZ_CP033665:c1709939-1709442 [Burkholderia glumae]
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT113988 WP_015877381.1 NZ_CP033665:c1710217-1709936 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT113988 NZ_CP033665:c1710217-1709936 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References