Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1702299..1703074 Replicon chromosome
Accession NZ_CP033654
Organism Burkholderia glumae strain YH67

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag EFO24_RS28095 Protein ID WP_015877380.1
Coordinates 1702299..1702796 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag EFO24_RS28100 Protein ID WP_015877381.1
Coordinates 1702793..1703074 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFO24_RS28060 1698320..1698415 - 96 Protein_1337 IS5/IS1182 family transposase -
EFO24_RS28065 1698487..1699032 - 546 Protein_1338 IS3 family transposase -
EFO24_RS28070 1699225..1700030 + 806 WP_085962370.1 IS5 family transposase -
EFO24_RS28075 1699996..1700307 - 312 WP_015877377.1 hypothetical protein -
EFO24_RS28080 1700324..1700575 - 252 WP_230674552.1 hypothetical protein -
EFO24_RS28085 1700705..1701307 - 603 Protein_1342 RHS domain-containing protein -
EFO24_RS28090 1701721..1702218 - 498 WP_015877379.1 ProQ/FINO family protein -
EFO24_RS28095 1702299..1702796 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
EFO24_RS28100 1702793..1703074 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
EFO24_RS28105 1703071..1703448 - 378 WP_173941242.1 hypothetical protein -
EFO24_RS28110 1703531..1703893 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1698463..1699005 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T113982 WP_015877380.1 NZ_CP033654:c1702796-1702299 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T113982 NZ_CP033654:c1702796-1702299 [Burkholderia glumae]
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT113982 WP_015877381.1 NZ_CP033654:c1703074-1702793 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT113982 NZ_CP033654:c1703074-1702793 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References