Detailed information of TA system TA113980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 5410..6356
• Replicon: plasmid p2_YH67
• Accession: NZ_CP033650
• Organism: Burkholderia glumae strain YH67

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: C5AN91
• Locus tag: EFO24_RS00750
• Protein ID: WP_012732709.1
• Coordinates: 5823..6356 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: C5AN90
• Locus tag: EFO24_RS00745
• Protein ID: WP_012732708.1
• Coordinates: 5410..5826 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFO24_RS00725	1342..2421	+	1080	WP_012732706.1	ParB N-terminal domain-containing protein	-
EFO24_RS00730	2758..4089	+	1332	WP_012732707.1	hypothetical protein	-
EFO24_RS00735	4211..4537	+	327	WP_127913985.1	hypothetical protein	-
EFO24_RS00740	5077..5262	+	186	WP_017432454.1	hypothetical protein	-
EFO24_RS00745	5410..5826	+	417	WP_012732708.1	DUF2384 domain-containing protein	Antitoxin
EFO24_RS00750	5823..6356	+	534	WP_012732709.1	RES family NAD+ phosphorylase	Toxin
EFO24_RS00755	6526..6714	+	189	WP_017432455.1	hypothetical protein	-
EFO24_RS00760	7466..7750	+	285	WP_017432347.1	hypothetical protein	-
EFO24_RS00765	7764..8006	+	243	WP_124837682.1	hypothetical protein	-
EFO24_RS00770	8003..8248	+	246	WP_127913916.1	hypothetical protein	-
EFO24_RS00775	8305..8646	+	342	WP_012732710.1	hypothetical protein	-
EFO24_RS00780	8649..10484	+	1836	WP_012732711.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..141001	141001

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-168)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 19101.61 Da
• Isoelectric Point: 4.7118

>T113980 WP_012732709.1 NZ_CP033650:5823-6356 [Burkholderia glumae]
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE

Nucleotide

• Length: 534 bp

>T113980 NZ_CP033650:5823-6356 [Burkholderia glumae]
ATGATCCTCACGCCGTTGCAGGACATCACGGCCTATCGCATGCATGTGCCCAAGTGGGCCGTCGCGCCCACCAGCGGCGC
TGGCGCGGCCAAGGCCGGGGGGCGGGCCAACCGGATCGGTACGCCAGCGTTGTACCTGGCGCTGGAGGCGGCCACCGCGG
TGGCCGAGTACCAGCAGCTGTCGCCCCTGTTGCCGCCGGGCACGTTGGTGAGCTATCGCGTCACGGCCACGCCCGTGGTC
GATTTCACCGGCGGCTACCGTGTGGATCTCTGGCCGCCCCTCTGGGAGTCGTTCTTCTGCGACTGGCGGCATGACTGGTT
CAACGCGCGCATTGAGCCGCCCAGCTGGGTACTCGGCGACGAGGCAATCGCCTCCGGCGCCAAGGGCATCCTGTTTCGCT
CGACGCAGGCCGCCGGCGGCACGAACTTGGTGCTGTTCGTCGACCAGTTGGGGGAGGGCGATCGCGTGGATGTTCACGAC
CCGGCCGGCGCCTTGCCGCGCGATCAAGCGTCGTGGGTTGACTCGCCCGAATGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14709.55 Da
• Isoelectric Point: 6.4664

>AT113980 WP_012732708.1 NZ_CP033650:5410-5826 [Burkholderia glumae]
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG

Nucleotide

• Length: 417 bp

>AT113980 NZ_CP033650:5410-5826 [Burkholderia glumae]
ATGAGCACTCTCGCAGCAGCGCGAGCCCCCGCCGGCGGTCCGGCCCTGGCAAACTTTGACGCGTTTCTCAGCGCGCTACG
CGAGCCGGACACGGCCGCTCCCGTGCTGTCGGCTCGTCGCTACGTGGCGGCCCTCAACATCGACCTGCAGACGCTCGCGG
ACCAGGCTCACGTCCATCGCAACACCGTCGCGCGCGCGCCGCAGTCAGCCAGCGTCCAGCAGTTTCTGCGCGAGGCGATT
CGCGTGATCCGAGCCGCGACGGATCTGTCGGGCGACGTTCAACGCGCGCTGTTCTGGTATCGCAACGAGCCTCTGGCCGT
CTTCGATTACCAGACGGCCGAAACGCTGGTGTCGGCAGGGCGCGCCGATGACGTTGTGCGCTATGTGGCATCGCTCGAGG
CGGGCGCCGCCGGATGA

Structures

Toxin

• AlphaFold DB: A0A2J9GLU3

Antitoxin

• AlphaFold DB: A0A2J9GLX3