Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1710365..1711140 Replicon chromosome
Accession NZ_CP033643
Organism Burkholderia glumae strain YH43

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag EFO25_RS06810 Protein ID WP_015877380.1
Coordinates 1710365..1710862 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag EFO25_RS06815 Protein ID WP_015877381.1
Coordinates 1710859..1711140 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFO25_RS06775 1706386..1706481 - 96 Protein_1343 IS5/IS1182 family transposase -
EFO25_RS06780 1706553..1707098 - 546 Protein_1344 IS3 family transposase -
EFO25_RS06785 1707291..1708096 + 806 WP_085962370.1 IS5 family transposase -
EFO25_RS06790 1708062..1708373 - 312 WP_015877377.1 hypothetical protein -
EFO25_RS06795 1708390..1708692 - 303 WP_255220127.1 DUF2380 domain-containing protein -
EFO25_RS06800 1708771..1709373 - 603 Protein_1348 RHS domain-containing protein -
EFO25_RS06805 1709787..1710284 - 498 WP_015877379.1 ProQ/FINO family protein -
EFO25_RS06810 1710365..1710862 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
EFO25_RS06815 1710859..1711140 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
EFO25_RS06820 1711137..1711514 - 378 WP_173941242.1 hypothetical protein -
EFO25_RS06825 1711597..1711959 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1694735..1736688 41953
- flank IS/Tn - - 1706529..1707071 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T113975 WP_015877380.1 NZ_CP033643:c1710862-1710365 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T113975 NZ_CP033643:c1710862-1710365 [Burkholderia glumae]
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT113975 WP_015877381.1 NZ_CP033643:c1711140-1710859 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT113975 NZ_CP033643:c1711140-1710859 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References