Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1710373..1711148 Replicon chromosome
Accession NZ_CP033642
Organism Burkholderia glumae strain YH38

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag EE994_RS28130 Protein ID WP_015877380.1
Coordinates 1710373..1710870 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag EE994_RS28135 Protein ID WP_015877381.1
Coordinates 1710867..1711148 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EE994_RS28095 1706394..1706489 - 96 Protein_1343 IS5/IS1182 family transposase -
EE994_RS28100 1706561..1707106 - 546 Protein_1344 IS3 family transposase -
EE994_RS28105 1707299..1708104 + 806 WP_085962370.1 IS5 family transposase -
EE994_RS28110 1708070..1708381 - 312 WP_015877377.1 hypothetical protein -
EE994_RS28115 1708398..1708649 - 252 WP_230674552.1 hypothetical protein -
EE994_RS28120 1708779..1709381 - 603 Protein_1348 RHS domain-containing protein -
EE994_RS28125 1709795..1710292 - 498 WP_015877379.1 ProQ/FINO family protein -
EE994_RS28130 1710373..1710870 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
EE994_RS28135 1710867..1711148 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
EE994_RS28140 1711145..1711522 - 378 WP_173941242.1 hypothetical protein -
EE994_RS28145 1711605..1711967 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1694742..1736696 41954
- flank IS/Tn - - 1706537..1707079 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T113974 WP_015877380.1 NZ_CP033642:c1710870-1710373 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T113974 NZ_CP033642:c1710870-1710373 [Burkholderia glumae]
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT113974 WP_015877381.1 NZ_CP033642:c1711148-1710867 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT113974 NZ_CP033642:c1711148-1710867 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References