Detailed information of TA system TA113963

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4286811..4287646
• Replicon: chromosome
• Accession: NZ_CP033635
• Organism: Escherichia coli isolate ECCNB12-2

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CQP61_RS23840
• Protein ID: WP_097413541.1
• Coordinates: 4286811..4287188 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CQP61_RS23845
• Protein ID: WP_089620082.1
• Coordinates: 4287278..4287646 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CQP61_RS23815	4282332..4283330	+	999	WP_001304655.1	DNA-binding transcriptional regulator IdnR	-
CQP61_RS23820	4283408..4284910	+	1503	WP_001294574.1	DUF853 domain-containing protein	-
CQP61_RS23825	4285165..4286013	-	849	WP_121832071.1	DUF4942 domain-containing protein	-
CQP61_RS23830	4286110..4286307	-	198	WP_001349630.1	DUF957 domain-containing protein	-
CQP61_RS23835	4286327..4286814	-	488	Protein_4095	hypothetical protein	-
CQP61_RS23840	4286811..4287188	-	378	WP_097413541.1	TA system toxin CbtA family protein	Toxin
CQP61_RS23845	4287278..4287646	-	369	WP_089620082.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
CQP61_RS23850	4287726..4287947	-	222	WP_000692287.1	DUF987 domain-containing protein	-
CQP61_RS23855	4288034..4288510	-	477	WP_001186708.1	RadC family protein	-
CQP61_RS23860	4288526..4289005	-	480	WP_000860074.1	antirestriction protein	-
CQP61_RS23865	4289087..4289908	-	822	WP_097413542.1	DUF945 domain-containing protein	-
CQP61_RS23875	4290009..4290242	-	234	WP_053287870.1	DUF905 family protein	-
CQP61_RS23880	4290248..4290925	-	678	WP_001601175.1	hypothetical protein	-
CQP61_RS23885	4291044..4291928	-	885	WP_097413544.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4264595..4290925	26330

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13828.91 Da
• Isoelectric Point: 7.9086

>T113963 WP_097413541.1 NZ_CP033635:c4287188-4286811 [Escherichia coli]
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLISSIDILRARRATGLMTRSHYRMVNNITLGKHCEVKP

Nucleotide

• Length: 378 bp

>T113963 NZ_CP033635:c4287188-4286811 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCGGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTTAC
CAGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACGCCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGATGCGGTGAACTTTCTTGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAGCTTCATCGCAGTTAATCAGCAGCATTGATATTCTCCGGGCCCGCCGGGCGACCGGCCTGATGACCCGCAG
CCACTACAGAATGGTGAACAACATCACCCTGGGTAAACACTGTGAGGTGAAACCATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13636.51 Da
• Isoelectric Point: 7.3222

>AT113963 WP_089620082.1 NZ_CP033635:c4287646-4287278 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPKMKN

Nucleotide

• Length: 369 bp

>AT113963 NZ_CP033635:c4287646-4287278 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA