113949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2651334..2652166 Replicon chromosome
Accession NZ_CP033635
Organism Escherichia coli isolate ECCNB12-2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0D8W767
Locus tag CQP61_RS15795 Protein ID WP_000854697.1
Coordinates 2651792..2652166 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0D8WAR2
Locus tag CQP61_RS15790 Protein ID WP_001354195.1
Coordinates 2651334..2651702 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CQP61_RS15750 2646527..2647411 + 885 WP_001696588.1 50S ribosome-binding GTPase -
CQP61_RS15755 2647530..2648207 + 678 WP_001097365.1 hypothetical protein -
CQP61_RS15760 2648213..2648365 + 153 WP_001696589.1 DUF905 family protein -
CQP61_RS15765 2648466..2649284 + 819 WP_001234688.1 DUF945 domain-containing protein -
CQP61_RS15770 2649366..2649845 + 480 WP_000860074.1 antirestriction protein -
CQP61_RS15775 2649861..2650337 + 477 WP_001354455.1 RadC family protein -
CQP61_RS15780 2650400..2650621 + 222 WP_000692303.1 DUF987 domain-containing protein -
CQP61_RS15785 2650640..2651284 + 645 WP_045146861.1 hypothetical protein -
CQP61_RS15790 2651334..2651702 + 369 WP_001354195.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CQP61_RS15795 2651792..2652166 + 375 WP_000854697.1 TA system toxin CbtA family protein Toxin
CQP61_RS15800 2652163..2652315 + 153 Protein_2563 hypothetical protein -
CQP61_RS15805 2652391..2652588 + 198 WP_085975623.1 DUF957 domain-containing protein -
CQP61_RS15810 2652673..2653469 + 797 Protein_2565 DUF4942 domain-containing protein -
CQP61_RS15815 2653689..2654855 + 1167 WP_001215370.1 ABC transporter substrate-binding protein -
CQP61_RS15820 2654828..2656363 + 1536 WP_000224999.1 ABC transporter permease subunit -
CQP61_RS15825 2656363..2657016 + 654 WP_012311831.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14023.07 Da        Isoelectric Point: 7.1881

>T113949 WP_000854697.1 NZ_CP033635:2651792-2652166 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIELHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T113949 NZ_CP033635:2651792-2652166 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCGGATGAACGCGTGATTGAGCTGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13708.48 Da        Isoelectric Point: 6.8270

>AT113949 WP_001354195.1 NZ_CP033635:2651334-2651702 [Escherichia coli]
VSDTLPGTTHHDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHPDQAFPLPMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT113949 NZ_CP033635:2651334-2651702 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCACGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCCGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8W767

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WAR2

References