Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 381671..382512 Replicon chromosome
Accession NZ_CP033635
Organism Escherichia coli isolate ECCNB12-2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag CQP61_RS04455 Protein ID WP_000854822.1
Coordinates 382129..382512 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A243ZR83
Locus tag CQP61_RS04450 Protein ID WP_071587515.1
Coordinates 381671..382039 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CQP61_RS04430 379416..380234 + 819 WP_001234702.1 DUF945 domain-containing protein -
CQP61_RS04435 380325..380810 + 486 WP_000214317.1 antirestriction protein -
CQP61_RS04440 380825..381301 + 477 WP_072645454.1 RadC family protein -
CQP61_RS04445 381370..381591 + 222 WP_000692312.1 DUF987 domain-containing protein -
CQP61_RS04450 381671..382039 + 369 WP_071587515.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CQP61_RS04455 382129..382512 + 384 WP_000854822.1 type IV toxin-antitoxin system toxin CbtA Toxin
CQP61_RS04460 382503..382991 + 489 WP_001177592.1 hypothetical protein -
CQP61_RS04465 383003..383200 + 198 WP_000839263.1 DUF957 domain-containing protein -
CQP61_RS04470 383297..384142 + 846 WP_001280435.1 DUF4942 domain-containing protein -
CQP61_RS04480 384441..384947 + 507 WP_000228936.1 G/U mismatch-specific DNA glycosylase -
CQP61_RS04485 385004..385567 - 564 WP_001183949.1 NADAR family protein -
CQP61_RS04490 385626..387467 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T113941 WP_000854822.1 NZ_CP033635:382129-382512 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T113941 NZ_CP033635:382129-382512 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13631.41 Da        Isoelectric Point: 6.6244

>AT113941 WP_071587515.1 NZ_CP033635:381671-382039 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT113941 NZ_CP033635:381671-382039 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A243ZR83

References